Reply To: Topical Flutamide Home › Hair Loss Forums › General Hair Loss › Topical Flutamide › Reply To: Topical Flutamide Author Replies Jetman # Posted on at Hey guys. Has anyone else here tried topical Flutamide besides me? Just wondering. I’ve been using it for almost 2 months without any side effects. Hair is thicker where I apply it(frontal hairline). It is a powerful anti-androgen that some doctors prescribe for hairloss. There is currently no data to prove or disprove the effectiveness. The ORAL type of Flutamide SHOULD NEVER BE TAKEN FOR HAIRLOSS. Good luck to all.