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Nano droplet CoQ10 delivery promises higher absorption

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by Jacob » September 15, 2008 at 11:11 am #97374

Talk about doing this with things such as resveratrol too.

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Nano droplet CoQ10 delivery promises higher absorption
By Lorraine Heller

15-Sep-2008 – A new delivery system for CoQ10 could increase its bioavailability by up to seven times, according to its US marketer SourceOne Global Partners.

Vesisorb, developed by Swiss firm Vesifact, uses nanotechnology to increase peak absorption rates of CoQ10 – both from supplements and foods.

According to SourceOne, which has exclusive global licensing rights for the technology, its major differentiation point is that unlike nanotechnology-based systems that use nanoparticles to deliver nutrients, Vesisorb uses nanosized droplets, which are absorbed “naturally” by the body.

This could potentially allow supplement manufacturers to develop products that deliver through one capsule the same level of CoQ10 into the human bloodstream as is received from seven to ten capsules of softgel products currently on the market, the firm’s president and CEO Jesse Lopez told NutraIngredients-USA.com.

CoQ10 benefits… and challenges

CoQ10 – or coenzyme Q10 – is a powerful antioxidant, which plays a vital role in the production of chemical energy in mitochondria – the ‘power plants’ of the cell – by participating in the production of adenosince triphosphate (ATP), the body’s co-called ‘energy currency’.

It has been studied for its role in cognitive health, heart health, and anti-ageing (in oral and topical formulations). It has also been shown to benefit those suffering from angina, heart attack and hypertension.

Its use in supplements, particularly in the US, has been boosted by the rise in popularity of statin drugs which deplete the body’s natural stores of CoQ10.

However, CoQ10 is not easily absorbed by the body, which has spurred the need for innovation in the sector to improve its bioavailability – or the levels that reach the human bloodstream.

Although nanotechnology has been one route chosen in the drive for bioavailability, the supplements industry still treads carefully in this field, which remains underdeveloped. A major concern has been the lack of understanding of what happens to nanoparticles once they enter the body.

Just this year, ingredients firm BASF exited the global CoQ10 market after only two years. The reason, it said, was that consumers had not well received the boosted bioavailability and high absorption claims derived from its nanotechnology-driven encapsulation process.

Nono droplets

SourceOne claims its technology would not raise similar concerns because it works by mimicking the body’s natural digestive function and absorption process.

Vesisorb is described as a natural self assembling association colloid (or nanocolloid) system. It is used to produce a proprietary CoQ10 formulation called CoQsource, which is a lipid-based formulation that naturally self-assembles on contact with an aqueous phase into an association colloid delivery system.

Essentially, this means that the technology takes insoluble, poorly-absorbed lipophilic (fat-loving) ingredients – such as CoQ10 – and solubalizes them. Once they are exposed to the aqueous environment in the stomach, they self-assemble into tiny fluid droplets.

These droplets are said to be very similar to the nanosized fluid droplets – or micelles – that the body normally manages when digesting high-fat foods, in order to make them easier to absorb.

“With our technology, we’ve basically ‘pre-digested’ the CoQ10, almost mirroring the body’s natural digestive process,” Lopez told NutraIngredients-USA.com.

Although this method has been used before in drug delivery and in cosmetics, Lopez said this was the first time this kind of technology – using nano fluid particles – was being applied to the food and supplement sectors.

Implementation and efficacy

Implementing the technology is “very simple”, he said. CoQSource, w

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by Jacob » September 15, 2008 at 11:25 am #97375

Besides the Douglas Labs product- Caplique…there’s also Emerson Ecologics(which uses the DL ingredient) Citrus Solu-Q:

Not as expensive as the liposomal ones..will probably switch to this for awhile(from Q-gel and ubiquinol).

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by Jacob » September 15, 2008 at 11:44 am #97378

And in these packets…hmmmmmm:

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by Jacob » April 25, 2009 at 11:24 am #118619

For Nid.. Resveratrol VESIsorb (Vineatrol)

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by MG63 » April 26, 2009 at 8:40 am #118702

Jacob — where can you buy Vineatrol?

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by Jacob » April 26, 2009 at 10:35 am #118706

I’m not sure if it’s available for sale yet. It’s just something they do make and I’m sure are waiting for someone like Douglas Labs to pick up and offer.

I have sent them an email asking if it is available out there. I’ll post any response I get.

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by MG63 » April 27, 2009 at 5:24 am #118789

thanks Jacob

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by nidhogge » May 11, 2009 at 12:50 am #120448

This is kick-ass! Definitely would be interested in trying out the res. version…

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by Jacob » November 18, 2009 at 8:30 pm #131439

I know at least one person here was taking this. It’s now available in “bulk”..powder:

I’ve noticed a lot of other companies picking up this stuff. Such as


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by Lapwing » November 18, 2009 at 8:36 pm #131440

First promising thing I heard in a while.


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by Jacob » November 18, 2009 at 9:53 pm #131445

This *may* be the cheapest source:


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by Lapwing » November 19, 2009 at 12:16 pm #131448

Do they have to something special to keep droplets nano size? Won’t the droplets start to from into larger groups again and defeat the whole purpose? Sounds like it would a very short shelf-live or perhaps they put in some very unnatural additives to keep it nano?


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by Jacob » November 19, 2009 at 6:37 pm #131456

Well they’ve done studies or whatever..so there must be something to it. All good questions for the company though.


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by Jacob » November 19, 2009 at 9:04 pm #131461

“For centuries, Ayurvedic practitioners relied on a curious substance called shilajit to treat or prevent a host of health problems. Culled from ancient biomass high in the Himalayas, shilajit was prized for its evident power to restore energy, increase fertility, enhance immunity, and safeguard memory against the effects of aging.
What is Shilajit?

Modern science has confirmed that shilajit is in fact an adaptogen and a super-vitalizer.1-3 Adaptogens are substances that provide broad-spectrum protection throughout the body by helping it adapt to internal and external stressors. Recent research indicates that shilajit achieves these benefits through highly specific effects that restore and sustain cellular energy, particularly through enhanced production of ATP, the vital molecular power source we need to survive.

The latest studies reveal an even more remarkable finding: When shilajit is combined with CoQ10, cellular energy gains increase dramatically. Together they optimize mitochondrial energy levels, activating a super-vitalization of our mitochondria’s ability to convert food into energy. This adaptogenic combination not only radically ramps up available energy — it enhances mitochondrial health, a vital factor in preventing aging at the cellular level.”

That’s from LEF..they have a product that contains it. You may remember that Reverse product that contains resv and shilajit and some form of b12. Swanson’s also now carries shilajit.


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by Lapwing » November 20, 2009 at 12:53 pm #131462

Shilajit is humus or dirt (aka biomass). Dirt is a redflag. Exotic places such as the Himalayas is another redflag

Adaptogen is another red flag. It is a buzz word used for these “magical’ substances.

WTF is an adaptogen anyway? As defined in Wikipedia:

An adaptogen is nontoxic to the recipient.
An adaptogen produces a nonspecific response in the body—an increase in the power of resistance against multiple stressors including physical, chemical, or biological agents.
An adaptogen has a normalizing influence on physiology, irrespective of the direction of change from physiological norms caused by the stressor.
Under this definition, adaptogens would be nontoxic in normal doses, produce a general defensive response against stress, and have a normalizing influence on the body.[1]

It is claimed that adaptogenic herbs are distinct from other substances in their ability to balance endocrine hormones and the immune system, and they help the body to maintain optimal homeostasis.[1] Adaptogens are proposed to have a normalizing effect on the body and to be capable of either toning down the activity of hyperfunctioning systems or strengthening the activity of hypofunctioning systems. However, they are also proposed to be functional at the level of allostasis, which is a more dynamic reaction to long term stress, lacking the fixed reference points of homeostasis.

Wow now it is totally crystal clear to me. If it sounds like bullshit, smells like bullshit, it is probably bullshit.


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