Effect of the dual 5alpha-reductase inhibitor, dutasteride, on serum testosterone and body mass index in men with benign prostatic hyperplasia.
A new study measuring testosterone and body mass levels in men taking Avodart was just released with some good news. Men taking Avodart may experience a boost in Testosterone and a loss of weight (body mass). The bad news is, only the men in the study who had the lowest levels of testosterone to begin with lost a significant amount of weight.
OBJECTIVE: To investigate the effects of dutasteride on serum testosterone level and body mass index
(BMI) in men who received medical therapy for benign prostatic hyperplasia (BPH).
PATIENTS AND METHODS: In all, 120 patients with BPH were randomized to three treatment groups: tamsulosin 0.2 mg/day (alpha-blocker group), dutasteride 0.5 mg/day (dutasteride group), or tamsulosin 0.2 mg plus dutasteride 0.5 mg/day (combination group) for 1 year. For all patients the BMI and serum testosterone levels were checked at baseline and after 1 year of treatment.
RESULTS: Among the evaluable 107 patients, the dutasteride (33) and combination groups (37) had significantly greater increases in serum testosterone level (16.3% and 15%, respectively) than the alpha-blocker group (37; 0.3%) after 1 year of treatment (both P < 0.001). When analysed by baseline serum testosterone tertile, the increases in serum testosterone level among the dutasteride and combination group were greatest in the lowest tertile. For BMI, the dutasteride and combination group had mean decreases of 0.17 and 0.20 kg/m(2), respectively, at 1 year, whereas the alpha-blocker group had a mean increase of 0.04 kg/m(2). The decreases in BMI for the dutasteride and combination group were statistically significant only in the lowest tertile (P = 0.048 and 0.010, respectively).
CONCLUSION: Our results show that dutasteride treatment in men with BPH led to a significant increase in serum testosterone level and a significant decrease in BMI among those with relatively lower baseline serum testosterone levels.
Hong SK, Min GE, Ha SB, Doo SH, Kang MY, Park HJ, Yoon CY, Jeong SJ, Byun SS, Lee SE.
BJU Int. 2010 Apr;105(7):970-4. Epub 2009 Sep 29.
Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.