Hairgrowth methods (Hoffman-Laroche)

Patent:

United States Patent   5,470,861

Harmon   Nov. 28, 1995

Method of promoting hair growth.

 

Inventors:

Harmon; Charles S. (Bloomfield, NJ).

 

Assignee:

Hoffmann-La Roche Inc. (Nutley, NJ).

 

Appl No:

286,152

 

Filed:

Aug. 4, 1994

 

Abstract:

The use of the compound 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyridine-1-oxide represented by the formula ##STR1## as well as pharmaceutically acceptable salts, as topical agents to promote hair growth is disclosed.

19 Claims, No Drawings

 

References Cited:

U.S. Patent Documents

4,971,982     Nov, 1990     Altwood et al.     514/337

5,028,711     Jul, 1991     Stenzel et al.     546/196

Foreign Patent Documents

9056007     Dec, 1990     AU

9058725     Jan, 1991     AU

9059751     Jan, 1991     AU

9060134     Feb, 1991     AU

9065644     May, 1991     AU

0350805     Jul, 1989     EP

0400430     May, 1990     EP

0406656A1     Jun, 1990     EP

0410208A1     Jul, 1990     EP

0427606A1     Nov, 1990     EP

3926001A1     May, 1989     DE

2204868     May, 1988     GB

WO86/00616     Jan, 1986     WO

88/00822     Feb 1988     WO

WO92/14439     Mar, 1992     WO

Other References

Uno, et al. Cyclic Dynamics of Hair Follicles and Effect of Minoxidil on the Bald Scalps of Stumptailed Macaques, The American Journal of Dermatology 7(3):283-297 (1985).

Uno, et al. Stumptailed Macaques as a Model of Male Pattern Baldness Models Dermatol. vol. 3 pp. 159-169 (1987).

Uno, H., The Stumptailed Macaque as a Model for Baldness: Effects of Minoxidil, International Journal of Cosmetic Science 8, 63-71 (1986).

Abstract (Corresponding to WO 9214439) 1992.
Primary Examiner: Henley, III; Raymond
Assistant Examiner: Spivack; Phyllis G.
Attorney, Agent or Firm: Gould; George M., Johnston; George W., Coletti; Ellen Ciambrone