Home / Hair Loss Treatments / Treatment Patents / Stimulation of hair growth with minoxidil and a 5.alpha.-reductase inhibitor Stimulation of hair growth with minoxidil and a 5.alpha.-reductase inhibitor United States Patent 5,578,599 Diani, et al. Nov. 26, 1996 Inventors: Diani; Arthur R. (Mattawan, MI); Buhl; Allen E. (Portage, MI); Schostarez; Heinrich J. (Portage, MI). Assignee: The Upjohn Company (Kalamazoo, MI). Appl. No: 376,468 Filed: Jan. 20,1995 Related U.S. Application Data: Continuation of (including streamline cont.) Ser. No. 9,451, Jan. 27, 1993, abandoned, which is a continuation of Ser. No. 565,777, Aug. 10, 1990, abandoned. Intl. Cl.: A61K 31/505, A61K 31/44 Current U.S. Cl.: 514/275; 514/284 Field of Search: 514/284, 275 Abstract: An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium channel openers, such as minoxidil, cromakalim, pinacidil, or a compound selected frown the classes of s-triazine, thiane-1-oxide, benzopyran and pyridinopyran compounds; and a 5.alpha.-reductase inhibitors, 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one. The method comprises administering an effective amount of the potassium channel opener and administering an effective amount of the 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one whereby the promotion of hair growth is increase over the sole administration of the potassium channel opener. 4 Claims, No Drawings References Cited: U.S. Patent Documents 4,139,619 Feb, 1979 Chidsey, III 424/45 4,596,812 Jun, 1986 Chidsey, III et al. 514/256 4,684,635 Aug, 1987 Orentreich et al. 514/170 5,026,691 Jun, 1991 Kligman et al. 514/171 Foreign Patent Documents 0285382A2 Oct, 1988 EP 3615396A Nov, 1987 DE 1305017A Dec, 1989 JP WO87/00427 Jan, 1987 WO Primary Examiner: Cintins; Marianne M. Assistant Examiner: Moezie; M. Attorney, Agent or Firm: Corneglio; Donald L.