Use of sucralfate to treat baldness

United States Patent     5,618,798

Bar-Shalom, et. al.     Apr. 8, 1997

 

Inventors:

Bar-Shalom; Daniel (Rypevaenget 213, DK-2980 Kokkedal, DK); Bukh; Niels (Strandvejen 122, DK-2900 Hellerup, DK).

 

Appl. No:

247,478

 

Filed:

May 23, 1994

Related U.S. Application Data:

Continuation of (including streamline cont.) Ser. No. 47,078, Apr. 16, 1993, abandoned, which is a continuation of Ser. No. 613,559, Nov. 21, 1990, abandoned.

Foreign Application Priority Data:

Apr. 20, 1989 [DK]     1918

Intl. Cl.: A61K 31/70

Current U.S. Cl.: 514/53; 514/25; 514/54

Field of Search: 514/23, 25, 53, 59

 

Abstract:

A method of treating and/or preventing alopecia (baldness, deficient hair growth) comprises administering to a patient in need thereof a therapeutically or prophylactically effective amount of a sulfated mono-, di- or oligosaccharide or a derivative, salt or complex thereof. The saccharide is preferably polysulfated, such as a polysulfated disaccharide, in particular sucrose, or a derivative, complex or salt thereof. Especially interesting polysulfated disaccharides are sucrose pentasulfate, sucrose hexasulfate, sucrose heptasulfate and sucrose octasulfate, e.g. in the form of a potassium or sodium salt, or in the form of sucralfate.

15 Claims, No Drawings

References Cited:

U.S. Patent Documents

4,912,093     Mar, 1990     Michaeli     514/53

 

Foreign Patent Documents

136100     Sept, 1985     EP

161816     Nov, 1985     EP

182756     May, 1986     EP

211610     Feb, 1987     EP

107885     May, 1987     EP

230023     Jul, 1987     EP

245855     Nov, 1987     EP

277428     Aug, 1988     EP

295092     Dec, 1988     EP

297455     Jan, 1989     EP

97625     Jan, 1989     EP

107209      May, 1989     EP

334585     Sept, 1989     EP

354595     Feb, 1990     EP

46-10875     Sept, 1965     JP

850082     Jul, 1981      RU

936916     Sept, 1963     GB

1098935     Jan, 1968     GB

WO8900047     Jan, 1989     WO

WO8905645     Jun, 1989     WO

WO8905646     Jun, 1989     WO

WO8907932     Aug, 1989     WO

 

Other References

Cassero, Chemical Abstracts, vol. 105 (8) (1986) No. 66249f.

The Merck Manual, 15th ed (1987) pp. 2281-2282.

Couchman et al, Chemical Abstracts, vol. 108 (7), No. 565394.

Gonzalez, et al., Conn’s Current Therapy, 599-603 (1984); Latest Approved Method of Treatment for the Practicing Physician.

W. Scott Brooks, Jr., American Journal of Gastroenterology 80:206-209 (1985); Sucralfate: Nonulcer Uses.
Primary Examiner: Peselev; Elli
Attorney, Agent or Firm: Cooper; Iver P.