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Hair Loss Study Abstract: The effect of cyproterone acetate on hair roots and hair shaft diameter in androgenetic alopecia in females.
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Title
The effect of cyproterone acetate on hair roots and hair shaft diameter in androgenetic
alopecia in females.
Author
Peereboom-Wynia JD; van der Willigen AH; van Joost T; Stolz E
Address
Bronovo-Nebo Foundation, The Hague, The Netherlands.
Source
Acta Derm Venereol, 69: 5, 1989, 395-8
Abstract
Twenty female patients suffering from androgenetic alopecia were treated during one year
with 50 micrograms ethinyloestradiol plus 2 mg cyproterone acetate and additional 20 mg
cyproterone acetate on days 5-20 of the menstrual cycle. The control group consisted of
eight untreated female patients with androgenetic alopecia. The parameters used to
evaluate therapeutic results were trichogram, hair shaft diameter of full anagen and
number of hairs measuring less than 40 microns. Hair roots were epilated from two
locations of the scalp: fronto-cranial and left temporal (reference point). The trichogram
of the fronto-cranial scalp region showed an increase of anagens as well as a decrease of
telogens. These changes were statistically highly significant. Further, there was a
decrease of dysplastic/dystrophic forms. The left temporal scalp region showed no
significant differences. The mean hair shaft diameter of full anagen (n = 8) increased,
while the number of hairs measuring less than 40 microns (n = 8) decreased. The last two
findings showed no statistically significant differences. The therapeutic results warrant
the conclusion that cyproterone acetate seems to be effective in androgenetic alopecia in
women.
Language of Publication
English
Unique Identifier
90022124
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