|
|
| Title: Bicalutamide: a new antiandrogen for use in
combination with castration for patients with advanced prostate cancer. |
| Title Abreviation: Anticancer Drugs |
Date of Pub: 1996 Jan |
| Author: Blackledge G; Kolvenbag G; Nash A; |
| Issue/Part/Supplement: 1 |
Volume Issue: 7 |
Pagination: 27-34 |
| MESH Headings: Adult; Aged; Aged, 80 and over; Androgen Antagonists
(AD/AE/*TU); Anilides (AD/*TU); Antineoplastic Agents, Hormonal (AE/TU); Combined Modality
Therapy; Flutamide (AE/TU); Human; Male; Middle Age; Neoplasms, Hormone-Dependent
(*DT/SU); Orchiectomy; Prostatic Neoplasms (*DT/SU); Randomized Controlled Trials; -RN-; |
| Journal Title Code: A9F |
Publication Type: JOURNAL ARTICLE |
| Date of Entry: 961114N |
Entry Month: 9701 |
| Country: ENGLAND |
Index Priority: 2 |
| Language: Eng |
Unique Identifier: 96361722 |
| Unique Identifier: 96361722 |
ISSN: 0959-4973 |
| Abstract: Maximum androgen blockade, a relatively recent
development in the treatment of prostate cancer, combines medical or surgical castration
with antiandrogen therapy. A large randomized study comparing the non-steroidal
antiandrogen, bicalutamide, with flutamide, each in combination with luteinizing
hormone-releasing hormone (LHRH) analogs, showed that after a median follow-up of 49
weeks, the time to treatment failure was significantly longer for the bicalutamide
patients compared with the flutamide patients (p = 0.005). After a median follow up to 95
weeks, bicalutamide in combination with LHRH analog therapy produced at least
equivalent efficacy with flutamide in combination with LHRH analog therapy in terms of
time to treatment failure and equivalent efficacy in terms of survival. The tolerability
profile of bicalutamide, as based on reported findings and a literature review,
indicates a superior tolerability to that of currently available antiandrogens,
particularly with respect to diarrhea with a low incidence of treatment-related
withdrawals. |
| Abstract By: Author |
| Address: Medical Research Department, ZENECA Pharmaceuticals Ltd,
Mereside, Macclesfield, UK. |
| Number of References: 38 |
content2 |
|
