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| Title: Potassium channel conductance: a mechanism affecting hair
growth both in vitro and in vivo. |
| Title Abbreviation: J Invest Dermatol |
Date of Pub: 1992 Mar |
| Author: Buhl AE; Waldon DJ; Conrad SJ; Mulholland MJ; Shull KL;
Kubicek MF; Johnson GA; Brunden MN; Stefanski KJ; Stehle RG; et al; |
| Issue/Part/Supplement: 3 |
Volume Issue: 98 |
Pagination: 315-9 |
| MESH Headings: Animal; Benzopyrans (PD); Cells, Cultured; Hair
(*GD); Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Minoxidil (PD); Potassium Channels
(*PH); Pyrroles (PD); -RN-; |
| Journal Title Code: IHZ |
Publication Type: JOURNAL ARTICLE |
| Date of Entry: 920415N |
Entry Month: 9206 |
| Country: UNITED STATES |
Index Priority: 1 |
| Language: Eng |
Unique Identifier: 92185253 |
| Unique Identifier: 92185253 |
ISSN: 0022-202X |
| Abstract: The opening of intracellular potassium channels has been
suggested as a mechanism regulating hair growth. Enhancing the flux of potassium
ions is a mechanism shared by several structurally diverse antihypertensive agents
including minoxidil sulfate (the active metabolite of minoxidil), pinacidil, P-1075 (a
potent pinacidil analog), RP-49,356, diazoxide, cromakalim, and nicorandil. Of
these drugs, minoxidil, pinacidil, and diazoxide have been reported to elicit
hypertrichosis in humans. This potassium channel hypothesis was examined by testing these
drugs for effects on hair growth both in vitro and in vivo. For the in vitro
studies, mouse vibrissae follicles were cultured for 3 d with drug and the effects on hair
growth were measured by metabolic labeling. All drugs, except diazoxide, enhanced cysteine
incorporation into the hair shafts of the cultured vibrissae. Diazoxide was poorly
soluble and thus was tested only at low doses. Minoxidil, P-1075, cromakalim, and
RP-49,356 were also evaluated in vivo by measuring hair growth effects in balding
stumptail macaque monkeys. The drugs were administered topically to defined sites on
balding scalps once per day for 4-5 months and the amount of hair grown was
determined by monthly measurements of shaved hair weight. Three of the drugs
produced significant increases in hair weight whereas, the RP-49,356 had no effect.
These studies provide correlative evidence that the opening of potassium channels is an
important regulatory mechanism for hair growth. This provides the impetus for
further studies on this potentially important mechanism affecting hair biology. |
| Abstract By: Author |
| Address: Dermatology Research, Upjohn Company, Kalamazoo, Michigan
49001. |
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