|
|
| Title: Potassium channel conductance as a control mechanism in hair
follicles. |
| Title Abbreviation: J Invest Dermatol |
Date of Pub: 1993 Jul |
| Author: Buhl AE; Conrad SJ; Waldon DJ; Brunden MN; |
| Issue/Part/Supplement: 1 Suppl |
Volume Issue: 101 |
Pagination: 148S-152S |
| MESH Headings: Hair (*GD); Human; Potassium Channels (*PH);
-AA-; |
| Journal Title Code: IHZ |
Publication Type: JOURNAL ARTICLE |
| Date of Entry: 930811N |
Entry Month: 9310 |
| Country: UNITED STATES |
Index Priority: 1 |
| Language: Eng |
Unique Identifier: 93315888 |
| Unique Identifier: 93315888 |
ISSN: 0022-202X |
| Abstract: The opening of intracellular potassium channels is a
common mechanism of action for a set of anti-hypertensive drugs that includes the hair-growth-inducing
agent minoxidil. Recent work suggests potassium channel openers (PCOs) also influence hair
growth. Correlative studies demonstrate that a series of PCOs including minoxidil,
pinacidil, P-1075, an active pinacidil analog, RP-49,356, cromakalim, and
nicorandil maintain hair growth in cultured vibrissa follicles. Studies using
balding stumptail macaques verify that minoxidil, P-1075, and cromakalim but not
RP-49,356 stimulate hair growth. The definition of potassium channels and
documentation of drug effects on these channels is classically done using
electrophysiologic techniques. Such studies require the identification and isolation of
target cells. Both these are among the unsolved problems in the area of hair
biology. Estimating K+ flux using 86Rb+ as a K+ tracer is an accepted method of assessing
potassium channel conductance in other organ systems. Both pinacidil and RP-49,356 induce
measurable Rb+ flux in isolated vibrissa follicles and a hair epithelial cell line
whereas neither minoxidil nor minoxidil sulfate had measurable effects. Potassium channels
have been studied successfully in other organ systems using specific pharmacologic
blockers for the various channel subtypes. Blockers including glyburide,
tetraethylammonium, and procaine failed to inhibit minoxidil stimulation of cultured
follicles. The current explosion of knowledge on potassium channel biology, cloning of
channels, and continued progress in hair biology promise to clarify the role of K+
ions in the control of hair follicles. |
| Abstract By: Author |
| Address: Dermatology Research, Upjohn Company, Kalamazoo, MI 49001.
|
| Number of References: 34 |
content2 |
|
