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Hair Loss Study Abstract: Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth.
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Title
Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors,
cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse:
immunosuppression is not required for new hair growth.
Author
Iwabuchi T; Maruyama T; Sei Y; Adachi K
Address
Marine Biotechnology Institute, Kamaishi Laboratories, Iwate, Japan.
Source
J Dermatol Sci, 1995 Jan, 9:1, 64-9
Abstract
The effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase)
inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation
(anagen hair induction) in mouse were studied by topical application on the dorsal skin
surface during the telogen phase of the hair cycle. Single applications of cyclosporin A
and FK506 (10 to 100 nmol in 5 microliters of ethanol) induced new hair growth in 12 days
within the restricted area where the compounds were applied. On the other hand, ascomycin
and rapamycin did not initiate new anagen hairs even at higher doses (1 mumol in 5 to 10
microliters of ethanol). The effects of simultaneous application of the immunosuppressants
were also tested by a single topical application. Ascomycin did not inhibit the anagen
hair induction by cyclosporin A, but inhibited hair induction by FK506. Rapamycin
inhibited new hair growth induced by cyclosporin A and FK506. These results suggest that
the inhibition of PPIase is not required for the initiation of a new hair cycle in mice,
and that anagen hair induction caused by cyclosporin A and FK506 is not a result of
immunosuppression. The present results also indicate that a single application of an
adequate quantity of cyclosporin A and FK506 is sufficient to initiate new hair growth.
Language of Publication
LA=ENG
Unique Identifier
95244412
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