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Hair Loss Study Abstract: A murine model for inducing and manipulating hair follicle regression (catagen): effects of dexamethasone and cyclosporin A.
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Title
A murine model for inducing and manipulating hair follicle regression (catagen): effects
of dexamethasone and cyclosporin A.
Author
Paus R; Handjiski B; Czarnetzki BM; EichmÂuller S
Address
Department of Dermatology, University Hospital R. Virchow, Freie UniversitÂat Berlin,
Germany.
Source
J Invest Dermatol, 1994 Aug, 103:2, 143-7
Abstract
Most cases of hair loss are based on premature induction of follicle regression
(catagen). Deciphering the unknown regulation of catagen is therefore clinically
important, but catagen is also an excellent model for organ involution by rapid terminal
differentiation and for epithelial cell death (apoptosis). We here report an assay for the
controlled pharmacologic induction and manipulation of catagen follicles.
Dexamethasone-21-acetate (0.1%) was applied once daily to depilation-induced, growing
follicles (anagen VI) on the backs of C57 B1-6 mice. Characteristic catagen-associated
changes in skin color were photodocumented and assessed by morphometric histology. Topical
dexamethasone induced catagen-like follicles significantly earlier, more homogeneously,
and also more extensively than vehicle. This process was inhibited by high intraperitoneal
doses of cyclosporin A. In addition to its clinical relevance as a screening assay for
catagen-blocking drugs, this simple murine model is an attractive tool for dissecting the
molecular, cellular, and developmental biology of catagen.
Language of Publication
LA=ENG
Unique Identifier
94315287
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