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Hair Loss Study Abstract: Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia.
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Title
Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition
of massive catagen development, and relative protection from chemotherapy-induced alopecia.
Author
Maurer M; Handjiski B; Paus R
Address
Department of Dermatology, Charité Hospital, Humboldt-Universität zu Berlin, Germany.
Source
Am J Pathol, 150(4):1433-41 1997 Apr
Abstract
Selected immunophilin ligands (IPLs) are not only potent immunosuppressants but also
modulate hair growth. Their considerable side effects, however, justify at best topical
applications of these drugs for the management of clinical hair growth disorders.
Therefore, we have explored hair growth manipulation by topical cyclosporin A (CsA) and FK
506 in previously established murine models that mimic premature hair follicle regression
(catagen) or chemotherapy-induced alopecia, two major pathomechanisms
underlying human hair loss. We confirm that topical CsA and FK 506 induce active hair
growth (anagen) in the back skin of C57BL/6 mice with all follicles in the resting stage
(telogen) and show that both IPLs also inhibit massive, dexamethasone-induced, premature
catagen development in these mice. Furthermore, we demonstrate that CsA and FK 506 provide
relative protection from alopecia and follicle dystrophy induced by
cyclophosphamide, possibly by favoring the dystrophic anagen pathway of follicle response
to chemical damage. Although it remains to be established whether these IPLs exert the
same effects on human hair follicles, our study provides proof of the principle that
topical IPLs can act as potent manipulators of clinically relevant hair-cycling
pathomechanisms. This strongly encourages one to explore the use of topical IPLs in the
management of human hair growth disorders.
Language
Eng
Unique Identifier
97249093
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