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Hair Loss Study Abstract: The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque.
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Title
The effects of topical diazoxide on hair follicular growth and physiology of the
stumptailed macaque.
Author
Uno H, Kemnitz JW, Cappas A, Adachi K, Sakuma A, Kamoda H
Address
Wisconsin Regional Primate Research Center, University of Wisconsin-Madison 53715-1299.
Source
J Dermatol Sci, 1: 3, 1990 May, 183-94
Abstract
Diazoxide, an anti-hypertensive agent, has diverse pharmacologic effects;
hypertrichosis, hyperglycemia associated with suppression of insulin release, and
elevation of serum levels of androgens. Taking advantage of the hypertrichotic side
effects of diazoxide, we examined the effect of topical application of the drug on hair
regrowth in the bald frontal scalp of stumptailed macaques (Macaca arctoides); we also
monitored systemic side effects. Using 7 adult stumptails, we applied diazoxide (5%
solution in a vehicle) topically on the bald frontal scalp, once a day, 5 days per week.
Two of seven macaques had vehicle alone applied. Hair growth was monitored by photographic
recording (once every month) and by sequential analysis of folliculograms from biopsied
skin (once every 4 months). We also examined body weight, hematology, blood pressure,
heart rate, serum levels of testosterone and dihydrotestosterone, and glucose tolerance
for a 4-month period. All 5 diazoxide-treated animals showed thickening and maintenance of
the frontal hair during the entire treatment period (16 months). Analysis of
folliculograms showed progressive enlargement of hair follicular size and acceleration of
its cyclic growth from telogen to anagen phase and prolongation of anagen phase in all
treated animals. Controls showed no consistent progressive changes of follicular growth.
None of the animals treated with diazoxide showed abnormal changes in physical growth,
cardiovascular function, serum levels of androgens, glucose tolerance (including insulin
levels), or hematology.
Language of Publication
English
Unique Identifier
91197922
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