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| Title: An estrogen receptor pathway regulates the telogen-anagen hair
follicle transition and influences epidermal cell proliferation. |
| Title Abreviation: Proc Natl Acad Sci U S A |
Date of Pub: 1996 Oct 29 |
| Author: Oh HS; Smart RC; |
| Issue/Part/Supplement: 22 |
Volume Issue: 93 |
Pagination: 12525-30 |
| MESH Headings: Animal; Antineoplastic Agents (PD);
Bromodeoxyuridine (ME); Cell Differentiation; Cell Division; Epidermis (CY/ME); Estradiol
(AA/ME/PD); Estrogen Antagonists (PD); Female; Hair Follicle (*GD); Kinetics; Mice;
Receptors, Estrogen (*PH); Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; -RN-; |
| Journal Title Code: PV3 |
Publication Type: JOURNAL ARTICLE |
| Date of Entry: 961224N |
Entry Month: 9702 |
| Country: UNITED STATES |
Index Priority: 2 |
| Language: Eng |
Unique Identifier: 97057276 |
| Unique Identifier: 97057276 |
ISSN: 0027-8424 |
| Abstract: The hair follicle is a cyclic, self renewing
epidermal structure which is thought to be controlled by signals from the dermal papilla,
a specialized cluster of mesenchymal cells within the dermis. Topical treatments with
17-beta-estradiol to the clipped dorsal skin of mice arrested hair follicles in
telogen and produced a profound and prolonged inhibition of hair growth while
treatment with the biologically inactive stereoisomer, 17-alpha-estradiol, did not inhibit
hair growth. Topical treatments with ICI 182,780, a pure
estrogen receptor antagonist, caused the hair follicles to exit telogen and enter
anagen, thereby initiating hair growth. Immunohistochemical staining for the
estrogen receptor in skin revealed intense and specific staining of the nuclei of the
cells of the dermal papilla. The expression of the estrogen receptor in the dermal papilla
was hair cycle-dependent with the highest levels of expression associated with the
telogen follicle. 17-beta-Estradiol-treated epidermis demonstrated a similar number of
5-bromo-2'-deoxyuridine (BrdUrd) S-phase cells as the control epidermis above telogen
follicles; however, the number of BrdUrd S-phase basal cells in the control epidermis
varied according to the phase of the cycle of the underlying hair follicles and
ranged from 2.6% above telogen follicles to 7.0% above early anagen follicles. These
findings indicate an estrogen receptor pathway within the dermal papilla regulates the
telogen-anagen follicle transition and suggest that diffusible factors associated with the
anagen follicle influence cell proliferation in the epidermis. |
| Abstract By: Author |
| Address: Department of Toxicology, North Carolina State University,
Raleigh 27695-7633, USA. |
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