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Hair Loss Study Abstract: Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study
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Title
[Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled,
randomized double-blind study (author's transl)]
Original Title
Lokaltherapie der Alopecia androgenetica mit 17 alpha-Ostradiol. Eine kontrollierte,
randomisierte Doppelblindstudie.
Author
Orfanos CE; Vogels L
Source
Dermatologica, 161: 2, 1980, 124-32
Abstract
In a controlled, randomized double-blind study, 51 patients with androgenetic alopecia
and increased hair loss (telogen rate greater than 20%) were treated by local application
of hair lotions with and without 17 alpha-estradiol (0.025%) for a period of at least 6
months. Before and after therapy trichograms were taken and evaluated under standardized
conditions. In 63% of the treated patients a reduction of the amount of telogen hairs
appeared, whereas in the control group the same reduction was found in only 37% of the
cases. Similarly, in the treated group only 11% of the patients worsened, in contrast to
50% of the control group who showed an increased telogen rate (greater than 10%). The
amount of growing anagen hairs and of seborrhea did not change significantly in both
groups. Side effects were not seen. These findings indicate that hair lotions containing
17 alpha-estradiol may have a therapeutic value in reducing androgenetic hair loss, if
applied topically for a long period of time, similar to 17 beta-estradiol. However, no
regrowth of new hair was found.
Language of Publication
German
Unique Identifier
80246878
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