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Hair Loss Study Abstract: Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin A (Sandimmun), cyclosporin H and FK506
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Title
Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin
A (Sandimmun), cyclosporin H and FK506.
Author
Bavandi A; Meingassner JG; Becker S
Address
Sandoz Forschungsinstitut, Vienna, Austria.
Source
Exp Dermatol, 1: 4, 1992 Nov, 199-205
Abstract
Weaned hairless rats were fed a diet deficient in fat, magnesium and folacin. After
approximately 1 week, an erythematous dermatitis developed which was associated with
extreme generalized pruritus. Scratching led to excoriations and hemorrhagic crusting. The
acute stage (pruritic rash) resolved after several days and was followed by sporadic
non-itching relapses. Subsequent to the onset of symptoms, rats were treated orally, once
daily for 3 days with CyA, CyH or FK506. The immunosuppressants CyA and FK506 caused a
dose-dependent inhibition of symptoms in contrast to CyH. The immediate clinical response
was associated with changes in blood histamine, white blood cell counts and histological
parameters. Since CyH is known to lack immunosuppressive activity, these results may
indicate that the cutaneous changes induced by the nutritional deficiency are associated
with immunological abnormalities. The results may also indicate mechanisms influenced by
CyA and FK506 but not by CyH; for example, release of chemical mediators from inflammatory
cells.
Language of Publication
English
Unique Identifier
95093803
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