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Hair Loss Study Abstract: Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome.
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Title
Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic
ovary syndrome.
Author
Pucci E; Genazzani AD; Monzani F; Lippi F; Angelini F; Gargani M; Barletta D; Luisi M;
Genazzani AR
Address
Endocrinological Institute, University of Pisa, Italy.
Source
Gynecol Endocrinol, 9: 3, 1995 Sep, 221-8
Abstract
Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS). The
effectiveness of the antiandrogen flutamide alone was studied in 25 patients affected by
PCOS with severe hirsutism for a period of 24 months. Seventeen of these patients had not
been treated before and eight had had previous but unsatisfactory therapy. Nineteen
patients showed a normal body weight (BMI < 25 kg/m2) whereas six were obese (BMI >
35 kg/m2). A chemical and endocrinological evaluation and an assessment of the degree of
hirsutism, assigned by Ferriman-Gallwey score (mean 22 +/- 3.038), was performed under
baseline conditions. Patients started treatment with flutamide (Eulexin, Schering-Plough,
Kenilworth, USA) at the dose of 500 mg daily. A chronobiological assessment of
gonadotropin episodic secretion and of gonadotropin response to GnRH challenge (10
micrograms in bolus) was done before and on day 7 of flutamide administration. During
treatment, our patients showed a marked and significant reduction of hirsutism starting
from a score of 6 and reaching the maximum (9.6 + 2.1) at 24 months of therapy. No
relevant hormonal changes or side-effects were observed during therapy. Our data
demonstrate that hirsutism in PCOS can rapidly and markedly respond to treatment with
flutamide alone without important side-effects even if administered for a long period.
Language of Publication
English
Unique Identifier
96129340
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