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| Title: [Antiandrogens in monotherapy or combined therapy for
treatment of advanced cancer of the prostate] |
| Title Abreviation: Arch Esp Urol |
Date of Pub: 1989 |
| Author: Pavone-Macaluso M; Serretta V; Pavone C; Romano C;
Daricello G; |
| Issue/Part/Supplement: -HEADING- |
Volume Issue: 42 Suppl 2 |
Pagination: 197-205 |
| MESH Headings: Aged; Aged, 80 and over; Androgen Antagonists (*TU);
Anilides (*TU); Antineoplastic Agents (*TU); Combined Modality Therapy; Cyproterone
(AA/TU); English Abstract; Flutamide (*TU); Follow-Up Studies; Human; Imidazoles (TU);
Male; Middle Age; Neoplasm Staging; Orchiectomy; Prostatic Neoplasms (*DT/PA/TH); Support,
Non-U.S. Gov't; -RN-; |
| Journal Title Code: 6ZW |
Publication Type: JOURNAL ARTICLE |
| Date of Entry: 900814N |
Entry Month: 9010 |
| Country: SPAIN |
Index Priority: 3 |
| Language: Spa |
Unique Identifier: 90314472 |
| Unique Identifier: 90314472 |
ISSN: 0004-0614 |
| Abstract: This study undertaken on antiandrogens alone or in
combination for treatment of prostate cancer shows the efficacy of flutamide in advanced
prostate cancer. At 6 and 12 months after beginning treatment, 37% of the patients showed
an objective response. Patient follow up at 2 and 3 years revealed a partial response in
33% and 19%, respectively. In one patient with stage C carcinoma, a long-lasting complete
response was achieved, with a duration of approximately 3 years. A marked palliative
effect was observed. Transrectal ultrasound revealed prostate volume had decreased in 73%
of the patients and 86% showed functional improvement. Sexual function was not
substantially altered during treatment. Similarly, there was no dramatic increase in serum
testosterone. The foregoing findings demonstrate that flutamide monotherapy is an
effective treatment for prostatic cancer and can be chosen for younger patients who wish
to conserve their sexual potency. |
| Abstract By: Author |
| Transliterated/Vernacular Title: Antiandrógenos en monoterapia o
en terapia combinada para el tratamiento del cáncer de próstata avanzado. |
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