United States Patent 5,382,431

United States Patent 5,382,431

United States Patent	5,382,431
Pickart	Jan. 17, 1995

Tissue protective and regenerative compositions

Inventors:	Pickart; Loren R. (Bellevue, WA).
Assignee:	*Skin* *Biology*, Inc. (Bellevue, WA).
Appl. No.:	954,620
Filed:	Sept. 29, 1992

Intl. Cl.:	A61K 37/02
U.S. Cl.:	424/401; 424/195.1; 424/445; 424/484; 514/ 6; 514/928; 514/887
Field of Search:	424/630, 638, 641, 642, 650, 484, 520, 195.1, 401

References Cited [Referenced By:]

U.S. Patent Documents

3,758,682	Sept., 1973	Huber et al.	530/369
4,053,630	Oct., 1977	Yu et al.	424/289
4,156,737	May, 1979	Bertelli	424/287
4,283,386	Aug., 1981	Van Scott et al.	424/ 70
4,440,754	Apr., 1984	Sorenson	424/140
4,461,724	Jul., 1984	Konishi	260/112.5
4,503,047	May, 1985	Banfi et al.	424/195.1
4,551,431	Nov., 1985	Pierce	424/641
4,760,051	Jul., 1988	Pickart	424/630
4,767,753	Aug., 1988	Pickart et al.	514/ 18
4,863,897	Sept., 1989	Dede et al.	424/630
5,164,367	Nov., 1992	Pickart	514/ 6

Foreign Patent Documents

66283	Dec., 1982	EP
189182	Jul., 1986	EP
190736	Aug., 1986	EP
288278	Oct., 1988	EP
450398	Oct., 1991	EP
2044265	Oct., 1980	GB
2097256	Nov., 1982	GB
88/08695	Nov., 1988	WO
88/08851	Nov., 1988	WO
89/12441	Dec., 1989	WO
91/03488	Mar., 1991	WO
91/05797	May, 1991	WO
91/07431	May, 1991	WO
91/12267	Aug., 1991	WO
91/14437	Oct., 1991	WO

Other References

Sorenson, "Some Copper Coordination Compounds and Their Antiinflammatory and Antiulcer Activities", Inflammation 1(3):317-331 (1976).
Sorenson et al., "Development of Copper Complexes for Potential Therapeutic Use", Agents and Actions 8:305-325 (1981).

Johnson et al., "Cytotoxic Chelators and Chelates Inhibition of DNA Synthesis in Cultured Rodent and Human Cells by Aroylhydrazones and by a Copper (II) Complex of Salicylaldehyde Benzoyl Hydrazone", Inorg. Chem. Acta 67:159-165 (1982).

Raju et al., "Ceruloplasmin, Copper Ions, and Angiogenesis", J. Natl. Cancer Inst. 69:1183-1188 (Nov., 1982).

Pickart et al., "Inhibition of the Growth of Cultured Cells and an Implanted Fibrosarcoma by Aroylhydrazone Analogs of the Gly-His-Lys-Cu(II) Complex", Biochem. Pharm. 32:3868-3871 (1983).

Pickart et al., "The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-L-histidyl-L-lysine", Lymphokines 8:425-446 (1983).

Sorenson, "Copper Complexes: A Physiologic Approach to Treatment of Chronic Diseases", Comprehensive Therapy 11(4):49-64 (1985).

Bergren et al. "Improved Survival Using Oxygen Free Radical Scavengers in the Presence of Ischemic Bowel Anastomosis", (Am. Sur. 54:333-336 (Jun., 1988).

Niwa, "Lipid Peroxides and Superoxide Dismutase (SOD) Induction in Skin Inflammatory Diseases, and Treatment with SOD Preparations", Dermatologica 179 S1: 101-106 (1989).

Primary Examiner: Page; Thurman K.
Assistant Examiner: Spear; James M.
Attorney, Agent or Firm: Townsend and Townsend Khourie and Crew

Abstract

Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise precipitates formed by the complexation of peptone digests of various proteins with copper(II) salts, indium (III) salts, tin(II) salts and tin(IV) salts.

13 Claims, No Drawings