|
United States Patent 5,382,431
|
| United States Patent |
5,382,431 |
| Pickart |
Jan. 17, 1995 |
Tissue protective and regenerative compositions
| Inventors: |
Pickart; Loren R. (Bellevue, WA). |
| Assignee: |
Skin Biology, Inc. (Bellevue, WA). |
| Appl. No.: |
954,620 |
| Filed: |
Sept. 29, 1992 |
| Intl. Cl.: |
A61K 37/02 |
| U.S. Cl.: |
424/401; 424/195.1; 424/445; 424/484; 514/ 6; 514/928; 514/887 |
| Field of Search: |
424/630,
638, 641, 642, 650, 484, 520, 195.1, 401 |
References Cited [Referenced
By:]
U.S. Patent Documents
| 3,758,682 |
Sept., 1973 |
Huber et al. |
530/369 |
| 4,053,630 |
Oct., 1977 |
Yu et al. |
424/289 |
| 4,156,737 |
May, 1979 |
Bertelli |
424/287 |
| 4,283,386 |
Aug., 1981 |
Van Scott et al. |
424/ 70 |
| 4,440,754 |
Apr., 1984 |
Sorenson |
424/140 |
| 4,461,724 |
Jul., 1984 |
Konishi |
260/112.5 |
| 4,503,047 |
May, 1985 |
Banfi et al. |
424/195.1 |
| 4,551,431 |
Nov., 1985 |
Pierce |
424/641 |
| 4,760,051 |
Jul., 1988 |
Pickart |
424/630 |
| 4,767,753 |
Aug., 1988 |
Pickart et al. |
514/ 18 |
| 4,863,897 |
Sept., 1989 |
Dede et al. |
424/630 |
| 5,164,367 |
Nov., 1992 |
Pickart |
514/ 6 |
Foreign Patent Documents
| 66283 |
Dec., 1982 |
EP |
|
| 189182 |
Jul., 1986 |
EP |
|
| 190736 |
Aug., 1986 |
EP |
|
| 288278 |
Oct., 1988 |
EP |
|
| 450398 |
Oct., 1991 |
EP |
|
| 2044265 |
Oct., 1980 |
GB |
|
| 2097256 |
Nov., 1982 |
GB |
|
| 88/08695 |
Nov., 1988 |
WO |
|
| 88/08851 |
Nov., 1988 |
WO |
|
| 89/12441 |
Dec., 1989 |
WO |
|
| 91/03488 |
Mar., 1991 |
WO |
|
| 91/05797 |
May, 1991 |
WO |
|
| 91/07431 |
May, 1991 |
WO |
|
| 91/12267 |
Aug., 1991 |
WO |
|
| 91/14437 |
Oct., 1991 |
WO |
|
Other References
- Sorenson, "Some Copper Coordination Compounds and Their Antiinflammatory and
Antiulcer Activities", Inflammation 1(3):317-331 (1976).
Sorenson et al.,
"Development of Copper Complexes for Potential Therapeutic Use", Agents and
Actions 8:305-325 (1981).
Johnson et al., "Cytotoxic Chelators and Chelates Inhibition of DNA Synthesis in
Cultured Rodent and Human Cells by Aroylhydrazones and by a Copper (II) Complex of
Salicylaldehyde Benzoyl Hydrazone", Inorg. Chem. Acta 67:159-165 (1982).
Raju et al., "Ceruloplasmin, Copper Ions, and Angiogenesis", J. Natl. Cancer
Inst. 69:1183-1188 (Nov., 1982).
Pickart et al., "Inhibition of the Growth of Cultured Cells and an Implanted
Fibrosarcoma by Aroylhydrazone Analogs of the Gly-His-Lys-Cu(II) Complex", Biochem.
Pharm. 32:3868-3871 (1983).
Pickart et al., "The Biological Effects and Mechanism of Action of the Plasma
Tripeptide Glycyl-L-histidyl-L-lysine", Lymphokines 8:425-446 (1983).
Sorenson, "Copper Complexes: A Physiologic Approach to Treatment of Chronic
Diseases", Comprehensive Therapy 11(4):49-64 (1985).
Bergren et al. "Improved Survival Using Oxygen Free Radical Scavengers in the
Presence of Ischemic Bowel Anastomosis", (Am. Sur. 54:333-336 (Jun., 1988).
Niwa, "Lipid Peroxides and Superoxide Dismutase (SOD) Induction in Skin
Inflammatory Diseases, and Treatment with SOD Preparations", Dermatologica 179 S1:
101-106 (1989).
Primary Examiner: Page; Thurman K.
Assistant Examiner: Spear; James M.
Attorney, Agent or Firm: Townsend and Townsend Khourie and Crew
Abstract
Methods are provided for preparing compositions suitable for protecting irritated or
damaged skin from further oxidative and biochemical damage and thus
permitting natural healing processes to progress, for accelerating the rate of healing of
burns and surgical wounds, and for increasing the size of hair follicles and the rate of
hair growth. The compositions generally comprise precipitates formed by the complexation
of peptone digests of various proteins with copper(II) salts, indium (III) salts, tin(II)
salts and tin(IV) salts.
13 Claims, No Drawings
content2 |
|
