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Hair Loss Study Abstract: Quantitative evaluation of glandular and stromal compartments in hyperplastic dog
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Title
Quantitative evaluation of glandular and stromal compartments in hyperplastic dog
prostates: effect of 5-alpha reductase inhibitors.
Author
Laroque PA; Prahalada S; Molon-Noblot S; Cohen SM; Soper K; Duprat P; Peter CP; van
Zwieten MJ
Address
Merck Research Laboratories, Merck & Co., Riom, France.
Source
Prostate, 27: 3, 1995 Sep, 121-8
Abstract
The objective of this study was to determine the effects of 2 different 5-alpha
reductase inhibitors (finasteride and MK-0434) on the glandular and stromal compartments
of hyperplastic canine prostates. In this study, dogs received 1 of the 2 compounds
orally, at a dose of 1 mg/kg/day for 16 weeks; control dogs received a placebo. The
morphological changes in the glandular and stromal compartments in the prostate were
quantitated by a point-counting method on Masson's trichrome-stained sections. Treatment
with 5-alpha reductase inhibitors resulted in significant (P < or = 0.05) decreases in
mean prostatic volumes, microscopic evidence of prostatic atrophy, and significant (P <
or = 0.05) decreases in the absolute volumes of the prostatic glandular and stromal
compartments compared to controls. In finasteride-treated dogs, the mean percent change
from baseline was: epithelium, -52; lumens, -58; fibrovascular stroma, -41; and smooth
muscle, -29. In MK-0434-treated dogs, the mean percent change from baseline was:
epithelium, -77; lumens, -58; fibrovascular stroma, -38; and smooth muscle, -42. The
effect on the glandular compartment in dogs treated with MK-0434 was slightly greater than
in dogs treated with finasteride; however, the effect on the stroma was similar. These
results clearly demonstrate that inhibition of 5-alpha reductase enzyme activity affects
growth and maintenance of both glandular and stromal compartments of dog hyperplastic
prostates. It is likely that the decrease in size of the prostate in finasteride-treated
(Proscar) men is due to shrinkage of both glandular and stromal compartments.
Language of Publication
English
Unique Identifier
96004872
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