Stimulation of hair growth by peptide copper complexes

Stimulation of hair growth by peptide copper complexes

United States Patent	5,538,945
Pallenberg, et. al.	Jul. 23, 1996

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Method of promoting hair growth

ign="top">Inventors:


Pallenberg; Alexander J. (Duval, WA); Patt; Leonard M. (Seattle, WA); Trachy; Ronald E. (Bothell, WA).
Assignee:	ProCyte Corporation (Kirkland, WA).
Appl. No.:	261,475
Filed:	Jun. 17, 1994

Intl. Cl. :	A61K 38/04
Current U.S. Cl.:	514/6; 514/18; 514/19; 530/304
Field of Search:	514/6, 18, 19; 530/304

References Cited | [Referenced By:]

U.S. Patent Documents

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4,760,051	Jul., 1988	Pickart	514/6
4,767,753	Aug., 1988	Pickart	514/18
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5,177,061	Jan., 1993	Pickart	514/18
5,214,032	May, 1993	Pickart	514/16
5,252,559	Oct., 1993	Kronholm et al.	514/18
5,470,876	Nov., 1995	Proctor	514/492

Foreign Patent Documents

327263A1	Aug., 1989	EP
WO87/00427	Jan., 1987	WO
WO88/05653	Aug., 1988	WO

Other References

Uno, H. et al. Macaque and Rodent Models for the Screening of Drugs for Stimulating Hair Growth. Journal of Cutaneous Aging and Cosmetic Dermatology 1, 193-204 (1990).

Metzler, D. "Biochemistry", Academic Press, NY (1977). See p. 198 Table 4-2 .

Primary Examiner: Nucker; Christine M.
Assistant Examiner: Prickril; Benet
Attorney, Agent or Firm: Seed and Berry

Abstract

Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides chelated to copper at a molar ratio ranging from about 1:1 to 3:1, with the second position of the peptide from the amino terminus being histidine, arginine or a derivative thereof. The peptide-copper complexes may be formulated for administration by, for example, topical application or injection. Any affliction associate with hairloss, including hairloss associated with both androgenetic and secondary alopecia, may be treated with the peptide-copper complexes of this invention.

12 Claims, No Drawings