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Stimulation of hair growth by peptide copper complexes

United States Patent 5,538,945
Pallenberg, et. al. Jul. 23, 1996
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Method of promoting hair growth

ign="top">Inventors:
Pallenberg; Alexander J. (Duval, WA); Patt; Leonard M. (Seattle, WA); Trachy; Ronald E. (Bothell, WA).
Assignee: ProCyte Corporation (Kirkland, WA).
Appl. No.: 261,475
Filed: Jun. 17, 1994
Intl. Cl. : A61K 38/04
Current U.S. Cl.: 514/6; 514/18; 514/19; 530/304
Field of Search: 514/6, 18, 19; 530/304

References Cited | [Referenced By:]

U.S. Patent Documents

3,194,732 Jul., 1965 Neuhauser 167/58
3,551,554 Dec., 1970 Herschler 424/7
3,558,770 Jan., 1971 Gordon et al. 424/80
3,758,682 Sept., 1973 Huber et al. 424/177
3,767,784 Oct., 1973 Gluck 424/28
3,832,338 Aug., 1974 Huber et al. 260/113
4,022,888 May, 1977 Huber et al. 424/177
4,167,945 Sept., 1979 Gottlieb 128/334.R
4,177,261 Dec., 1979 Dietze et al. 424/101
4,263,428 Apr., 1981 Apple et al. 536/17.A
4,287,184 Sept., 1981 Young 424/177
4,440,788 Apr., 1984 Terayama et al. 424/320
4,665,054 May, 1987 Pickart 514/18
4,760,051 Jul., 1988 Pickart 514/6
4,767,753 Aug., 1988 Pickart 514/18
5,120,831 Jun., 1992 Pickart 530/331
5,177,061 Jan., 1993 Pickart 514/18
5,214,032 May, 1993 Pickart 514/16
5,252,559 Oct., 1993 Kronholm et al. 514/18
5,470,876 Nov., 1995 Proctor 514/492

Foreign Patent Documents

327263A1 Aug., 1989 EP  
WO87/00427 Jan., 1987 WO  
WO88/05653 Aug., 1988 WO  
Other References
Uno, H. et al. Macaque and Rodent Models for the Screening of Drugs for Stimulating Hair Growth. Journal of Cutaneous Aging and Cosmetic Dermatology 1, 193-204 (1990).

Metzler, D. "Biochemistry", Academic Press, NY (1977). See p. 198 Table 4-2 .


Primary Examiner: Nucker; Christine M.
Assistant Examiner: Prickril; Benet
Attorney, Agent or Firm: Seed and Berry

Abstract

Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides chelated to copper at a molar ratio ranging from about 1:1 to 3:1, with the second position of the peptide from the amino terminus being histidine, arginine or a derivative thereof. The peptide-copper complexes may be formulated for administration by, for example, topical application or injection. Any affliction associate with hair loss, including hair loss associated with both androgenetic and secondary alopecia, may be treated with the peptide-copper complexes of this invention.

12 Claims, No Drawings

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