United States Patent 4,919,664

United States Patent 4,919,664

United States Patent	4,919,664
Oliver, et. al.	Apr. 24, 1990

Stimulation of hair growth

Inventors:	Oliver; Roy F. (Department of Biological Sciences University of Dundee, Dundee, GB3); Jahoda; Colin A. B. (Department of Biological Sciences University of Dundee, Dundee, GB3), DD1 .
Appl. No.:	16,224
Filed:	Feb. 19, 1987

Foreign Application Priority Data

Feb. 21, 1986 [GB]

860436

Intl. Cl. :	A61F 2/10
Current U.S. Cl.:	623/15
Field of Search:	623/1, 2, 11, 12, 15, 16, 8; 128/1 R; 435/240.25

References Cited | [Referenced By:]

U.S. Patent Documents

4,185,618	Jan., 1980	Corey	128/1.R
4,353,888	Oct., 1982	Sefton	623/11
4,391,909	Jul., 1983	Lim	623/11
4,418,691	Dec., 1983	Yannas et al.	623/15
4,442,655	Apr., 1984	Stroetmann	623/11
4,508,819	Apr., 1985	Rose	128/1.R
4,661,447	Apr., 1987	Fabricius et al.	435/240.25
4,677,968	Jul., 1987	Krueger	128/1.R
4,721,096	Jan., 1988	Naughton et al.	128/1.R
4,742,120	Feb., 1987	Nevo et al.	623/15

Foreign Patent Documents

0013394	Jul., 1980	EP
0107885	May, 1984	EP

Other References

Jahoda et al., Vibrissa Dermal Papilla Cell Aggregative Behaviour in vivo and in vitro, J. Embryol. Exp. Morph., 79, 211-224 (1984).

Jahoda et al., Introduction of Hair Growth by Implantation of Cultured Dermal Papilla Cells, Nature, vol. 311, No. 5986, pp. 560-562, Oct. 1984.

Primary Examiner: Apley; Richard J.
Assistant Examiner: Isabella; David J.
Attorney, Agent or Firm: Irfan; Kareem M.

Abstract

The present invention relates to a method of stimulating hair growth in part of the skin of a mammal. The method comprises selecting lower follicular dermal cells and culturing them. An opening is then formed in the skin and the cultured dermal cells introduced through the opening in the outer epidermis layer of the skin into contact with the dermis, with said cultured dermal cells in association with epidermis cells.

The invention also provides a hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermis cells, as well as such cultured dermal cells for use in the preparation of an injection composition for stimulating hair growth in human skin.

14 Claims, No Drawings