|
Use of sucralfate to treat baldness |
| United States Patent | 5,618,798 |
| Bar-Shalom, et. al. | Apr. 8, 1997 |
Use of sucralfate to treat baldness
| Inventors: | Bar-Shalom; Daniel (Rypevaenget 213, DK-2980 Kokkedal, DK); Bukh; Niels (Strandvejen 122, DK-2900 Hellerup, DK). |
| Appl. No.: | 247,478 |
| Filed: | May 23, 1994 |
Related U.S. Application Data
| Continuation of (including streamline cont.) Ser. No. 47,078, Apr. 16, 1993, abandoned, which is a continuation of Ser. No. 613,559, Nov. 21, 1990, abandoned. |
Foreign Application Priority Data
| Apr. 20, 1989 [DK] | 1918 |
| Intl. Cl. : | A61K 31/70 |
| Current U.S. Cl.: | 514/53; 514/25; 514/54 |
| Field of Search: | 514/23, 25, 53, 59 |
References Cited | [Referenced By:]
U.S. Patent Documents
Foreign Patent Documents
| 136100 | Sept., 1985 | EP | |
| 161816 | Nov., 1985 | EP | |
| 182756 | May, 1986 | EP | |
| 211610 | Feb., 1987 | EP | |
| 107885 | May, 1987 | EP | |
| 230023 | Jul., 1987 | EP | |
| 245855 | Nov., 1987 | EP | |
| 277428 | Aug., 1988 | EP | |
| 279244 | Aug., 1988 | EP | |
| 295092 | Dec., 1988 | EP | |
| 297455 | Jan., 1989 | EP | |
| 97625 | Jan., 1989 | EP | |
| 107209 | May, 1989 | EP | |
| 334585 | Sept., 1989 | EP | |
| 354595 | Feb., 1990 | EP | |
| 46-10875 | Sept., 1965 | JP | |
| 850082 | Jul., 1981 | RU | |
| 936916 | Sept., 1963 | GB | |
| 1098935 | Jan., 1968 | GB | |
| WO8900047 | Jan., 1989 | WO | |
| WO8905645 | Jun., 1989 | WO | |
| WO8905646 | Jun., 1989 | WO | |
| WO8907932 | Aug., 1989 | WO |
The Merck Manual, 15th ed (1987) pp. 2281-2282.
Couchman et al, Chemical Abstracts, vol. 108 (7), No. 565394.
Gonzalez, et al., Conn's Current Therapy, 599-603 (1984); Latest Approved Method of Treatment for the Practicing Physician.
W. Scott Brooks, Jr., American Journal of Gastroenterology 80:206-209 (1985); Sucralfate: Nonulcer Uses.
Primary Examiner: Peselev; Elli
Attorney, Agent or Firm: Cooper; Iver P.
Abstract
A method of treating and/or preventing alopecia (baldness, deficient hair growth) comprises administering to a patient in need thereof a therapeutically or prophylactically effective amount of a sulfated mono-, di- or oligosaccharide or a derivative, salt or complex thereof. The saccharide is preferably polysulfated, such as a polysulfated disaccharide, in particular sucrose, or a derivative, complex or salt thereof. Especially interesting polysulfated disaccharides are sucrose pentasulfate, sucrose hexasulfate, sucrose heptasulfate and sucrose octasulfate, e.g. in the form of a potassium or sodium salt, or in the form of sucralfate.
15 Claims, No Drawings
