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Hair Loss Study Abstract: The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides).
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Title
The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum
testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca
arctoides). Author
Rhodes L, Harper J, Uno H, Gaito G, Audette-Arruda J, Kurata S, Berman C, Primka R,
Pikounis B Address
Merck Research Laboratories, Rahway, New Jersey 07065-0900.
Source
J Clin Endocrinol Metab, 79: 4, 1994 Oct, 991-6
Abstract
Finasteride, a 5 alpha-reductase inhibitor, was administered orally (1 mg/kg.day) for 6
months to six male and five female stumptail macaques. Vehicle was given to five male and
five female animals over the same period of time. Hair weights in a defined 1-in.2 area of
frontal scalp were measured periodically every 1-2 months, and serum was collected for
measurement of testosterone and dihydrotestosterone. In addition, scalp biopsies were
taken before and 6 months after treatment to evaluate the micromorphometry of hair
follicles. Results showed that both male and female serum dihydrotestosterone levels were
significantly reduced (60-70%) by finasteride treatment. Both males and females showed
statistically significant increases in mean hair weight over the treatment period compared
to controls (P = 0.034). In addition, there was a statistically significant increase in
mean follicle length (measured histologically in scalp biopsies) compared to baseline in
the finasteride-treated animals (P = 0.028). These data show that an inhibition of 5
alpha-reductase in the stumptail macaque can reverse the balding seen with age in both the
male and female animals.
Language of Publication English
Unique Identifier 95051280
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