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Hair Loss Study Abstract: 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review.
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| Title: 5 alpha-metabolism in finasteride-treated subjects
and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency.
A review. |
| Title Abreviation: Eur Urol |
Date of Pub: 1991 |
| Author: Imperato-McGinley J; |
| Issue/Part/Supplement: -HEADING- |
Volume Issue: 20 Suppl 1 |
Pagination: 78-81 |
| MESH Headings: Aged; Androstenes (*TU); Azasteroids (*TU);
Comparative Study; Double-Blind Method; Human; Male; Middle Age; Prostatic Hyperplasia
(DT); Pseudohermaphroditism (*DT/EN); Stanolone (ME); Testosterone 5-alpha-Reductase
(*AI/*DF/ME); -RN-; |
| Journal Title Code: ENM |
Publication Type: CLINICAL TRIAL |
| Date of Entry: 920211N |
Entry Month: 9204 |
| Country: SWITZERLAND |
Index Priority: 2 |
| Language: Eng |
Unique Identifier: 92104209 |
| Unique Identifier: 92104209 |
ISSN: 0302-2838 |
| Abstract: Male pseudohermaphrodites (MPHs) with inherited 5 alpha-reductase
deficiency and decreased dihydrotestosterone production have a global defect in 5 alpha-metabolism
affecting both C19 androgen metabolism and C21 steroid metabolism. However, the decreased
5 alpha-reduction of testosterone to dihydrotestosterone is the only impaired
steroid conversion to have clinical consequences, e.g., ambiguous genitalia, impaired
prostate differentiation and development, and decreased facial and body hair. The 5
alpha-steroid metabolite profile in the MPHs was compared with that of men with
benign prostatic hyperplasia who were administered varying doses of the 5 alpha-reductase
inhibitor finasteride. Finasteride was found to be a potent inhibitor of both C19 androgen
and C21 5 alpha-steroid metabolism affecting both hepatic and peripheral 5 alpha-metabolism.
The 5 alpha-steroid metabolite profile was strikingly similar to that of MPHs with
inherited 5 alpha-reductase deficiency. The data suggest that a 5 alpha-reductase
gene codes for an enzyme with affinity for multiple steroid substrates. |
| Abstract By: Author |
| Address: Department of Medicine, Cornell University Medical
College, New York, NY. |
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