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Hair Loss Study Abstract: Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity.
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Title
Local and systemic reduction by topical finasteride or flutamide of hamster flank organ
size and enzyme activity.
Author
Chen C; Puy LA; Simard J; Li X; Singh SM; Labrie F
Address
MRC Group in Molecular Endocrinology, CHUL Research Center, Québec, Canada.
Source
J Invest Dermatol, 105: 5, 1995 Nov, 678-82
Abstract
The hamster flank organ is a widely used model of the control of sebaceous gland
activity by androgens and anti-androgens. Finasteride, a 5 alpha-reductase inhibitor, was
administered locally on the surface of the right flank organ and right ear twice daily for
4 weeks. The treatment caused similar 12% to 30% reductions in the size of the sebaceous
glands in both flank organs. Moreover, relative mRNA levels of the androgen-regulated
FAR-17a gene measured by in situ hybridization as well as [3H]-thymidine incorporation and
5 alpha-reductase activity were similarly decreased in the two flank organs after topical
application. The pure anti-androgen flutamide, at the same doses, exerted a more potent
effect on all the same parameters, and the effect was also comparable on both the treated
and untreated sides of flank organs. Finasteride and flutamide significantly decreased
ventral and dorsal prostatic weights after topical application. The present data show that
the topical administration of finasteride, in analogy with flutamide, causes local
inhibition of sebaceous gland growth in both the costovertebral organs and ears. However,
as demonstrated by the similar inhibitory effect in the contralateral untreated side and
the reduced weight of the dorsal and ventral lobes of the prostate and seminal vesicles,
finasteride and flutamide both exert significant systemic effects.
Language of Publication
English
Unique Identifier
96067284
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