Hairloss Study Abstract: Parathyroid Hormone Study

Hairloss Study Abstract: Parathyroid Hormone Study

Title

Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

Author

Wysolmerski JJ; Broadus AE; Zhou J; Fuchs E; Milstone LM; Philbrick WM

Address

Department of Medicine, Yale University School of Medicine, New Haven, CT 06510.

Source

Proc Natl Acad Sci U S A, 91(3):1133-7 1994 Feb 1

Abstract

Parathyroid hormone-related peptide (PTHrP) was initially discovered as the cause of the syndrome of humoral hypercalcemia of malignancy. Subsequently, the PTHrP gene has been shown to be expressed in a wide variety of normal tissues, including skin. Because the biological function of PTHrP in skin remains unknown, we used the human keratin 14 promoter to target overexpression of PTHrP to the skin of transgenic mice. We achieved a 10-fold level of overexpression in skin, and human keratin 14 promoter-PTHrP transgenic mice displayed a disturbance in normal hair follicle development. These mice either failed to initiate follicle development or showed a delay in the initiation of follicles. These findings suggest that PTHrP normally plays a role in the early stages of hair follicle development and support previous speculation that the peptide may function in regulating cellular differentiation.

Language

Eng

Unique Identifier

94134712