|
|
|
Hair Loss Study Abstract: Local inhibition of sebaceous gland growth by topically applied RU 58841.
|
Title
Local inhibition of sebaceous gland growth by topically applied RU 58841.
Author
Matias JR, Gaillard M
Address
Nova Biosciences, Norrie Point Research Station, Staatsburg, New York 12553, USA.
Source
Ann N Y Acad Sci, 761:1995 Jun 12, 56-65
Abstract
The biological activity of a series of nonsteroidal, pure androgen receptor inhibitors
was compared using the Syrian hamster ear skin sebaceous gland model. RU 58841, RU 56187,
RU 38882 and cyproterone acetate were applied topically for 4 weeks on the ventral ear
pinna of sexually mature male Syrian hamsters. Their order of efficacy was as follows: RU
58841 > RU 56187 > RU 38882 > cyproterone acetate. Maximal reduction of 60% in
the size of the sebaceous glands was observed in hamsters treated with RU 58841 at a dose
of 10 micrograms per day. This degree of inhibition occurred without any systemic side
effects as shown by the absence of inhibition on the contralateral untreated ear pinna.
Longer treatment did not produce greater inhibition since extending the treatment period
from 4 weeks to 12 weeks showed similar data. The effect of RU 58841 was reversible since
the inhibited sebaceous glands returned to normal size within 4 weeks after the cessation
of the topical applications. The potent localized inhibition of sebaceous glands by RU
58841 demonstrates the excellent potential of this compound as a topical drug for the
treatment of acne and other androgen-mediated disorders.
Language of Publication
English
Unique Identifier
95351703
content2 |
|
