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| Title: Inhibition of hair growth by testosterone in the presence of
dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. |
| Title Abreviation: Endocrinology |
Date of Pub: 1997 Jan |
| Author: Obana N; Chang C; Uno H; |
| Issue/Part/Supplement: 1 |
Volume Issue: 138 |
Pagination: 356-61 |
| MESH Headings: Alopecia*; Animal; Cell Division*; Cells, Cultured*;
Female; Hair*; Imidazoles*; Macaca*; Male; Nitriles*; Skin*; Support, Non-U.S. Gov't;
Support, U.S. Gov't, P.H.S.; Testosterone*; -PG-; |
| Journal Title Code: EGZ |
Publication Type: JOURNAL ARTICLE |
| Date of Entry: 970123N |
Entry Month: 9703 |
| Country: UNITED STATES |
Index Priority: 1 |
| Language: Eng |
Unique Identifier: 97131967 |
| Unique Identifier: 97131967 |
ISSN: 0013-7227 |
| Abstract: Hair-follicle regression in the bald scalps of
stumptailed macaques develops after puberty, which corresponds to an elevation of serum
testosterone and dihydrotestosterone. Using the cultured cells from the pre- and
postpubertal macaques, we examined the role of dermal papilla cells in
testosterone-induced inhibition of outer root sheath cell proliferation. Testosterone
showed no effects on proliferation of either dermal papilla cells or outer root sheath
cells cultured alone. Testosterone-induced inhibition of outer root sheath cell
proliferation occurred only in coculture with dermal papilla cells derived from the bald
scalps of adult macaques but not with dermal papilla cells from the hairy occipital scalps
of adult macaques or the prebald frontal scalps of juvenile macaques. Furthermore, RU 58841,
an androgen receptor blocker, antagonized this testosterone-elicited inhibition. Together
our data indicate that the inhibitory effect of testosterone on proliferation of
epithelial cells is age dependent, and androgen may play an essential role in hair growth
either by inducing repressor(s) from dermal papilla cells, which may then inhibit the
growth of epithelial cells of the hair follicle, or by inducing growth factor(s) from
dermal papilla cells, which, in turn, may trigger the induction of some repressors in
epithelial cells, thereby inhibiting the epithelial cell growth. Our animal studies also
showed that RU 58841 has a dramatic effect on hair regrowth in the bald frontal
scalp of the stumptailed macaque, which may further support our in vitro culture studies
showing that antiandrogens can antagonize testosterone-elicited hair growth. In summary,
our studies may provide a model for further isolation of androgen-regulated
repressor(s)/growth factors, which may help control hair growth and baldness. |
| Abstract By: Author |
| Address: Regional Primate Research Center, University of Wisconsin,
Madison 53715-1299, USA. |
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