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Hair Loss Study Abstract: Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers.
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Title
Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of
5-alpha reductase in healthy male volunteers.
Author
Strauch G; Perles P; Vergult G; Gabriel M; Gibelin B; Cummings S; Malbecq W; Malice MP
Address
Eclimed Pharmacologie Clinique, Hôpital Universitaire Cochin, Paris, France.
Source
Eur Urol, 26: 3, 1994, 247-52
Abstract
A total of 32 healthy male volunteers (age range 20-30 years) were enrolled in a 1-week
open, randomized, placebo-controlled study comparing finasteride (Proscar), a 5
alpha-reductase inhibitor, with Permixon, the plant extract of Serenoa repens. The
objective of the study was to evaluate the effect of single and multiple doses of the
drugs on the inhibition of 5 alpha-reductase as assessed by serum dihydrotestosterone
level determination. Following baseline measurements on day 1, the subjects were
randomized to finasteride 5 mg once a day (n = 10), Permixon 80 mg x 2 twice a day (n =
11), or to placebo once a day (n = 11) for 7 days. Serum testosterone and
dihydrotestosterone levels, were determined on day 1 (baseline and 12 h) and on days 2 (24
h), 3 (48 h), 4 (72 h), 6 (120 h), and 8 (168 h). After 12 h, a single dose of finasteride
5 mg reduced the serum dihydrotestosterone level by 65% (p < or = 0.01). The decreases
ranged from -52 to -60% with multiple doses of finasteride 5 mg once a day (p < or =
0.01). As in the placebo group, there was no effect of Permixon on the serum
dihydrotestosterone level. No significant difference was detected between finasteride and
Permixon or between finasteride and placebo with respect to serum testosterone, except on
days 3 and 6, respectively (p < or = 0.05). However, the corresponding serum
testosterone levels remained within the normal ranges. These data confirm the efficacy of
finasteride as inhibitor of 5 alpha-reductase.(ABSTRACT TRUNCATED AT 250 WORDS)
Language of Publication
English
Unique Identifier
95104266
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