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Hair Loss Study Abstract: Topical application of nitroxide protects radiation-induced alopecia in guinea pigs.
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Title
Topical application of nitroxide protects radiation-induced alopecia in guinea pigs.
Author
Goffman T, Cuscela D, Glass J, Hahn S, Krishna CM, Lupton G, Mitchell JB
Address
Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
Source
Int J Radiat Oncol Biol Phys, 22: 4, 1992, 803-6
Abstract
We have recently found that treatment of Chinese hamster V79 cells with the stable
nitroxide radical TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) afforded
significant protection against superoxide, hydrogen peroxide, and X-ray mediated
cytotoxicity. Radiation-induced alopecia is a common radiotherapeutic problem. Topical
application of TEMPOL was evaluated for possible protective effects against
radiation-induced alopecia using guinea pig skin as a model. For single acute X-ray doses
up to 30 Gy, TEMPOL, when topically applied 15 min prior to irradiation provided a marked
increase in the rate and extent of new hair recovery when compared to untreated skin.
TEMPOL was detected in treated skin specimens with electron paramagnetic resonance (EPR)
spectroscopy. Similar measurements of blood samples failed to show any signal resulting
from topical application, nor could TEMPOL be detected in brain tissue after application
on the scalp. TEMPOL represents a new class of compounds with potential for selective
cutaneous radioprotection without systemic absorption.
Language of Publication
English
Unique Identifier
92184624
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