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Hair Loss Study Abstract: Antiandrogenic activity and endocrinological profile of a novel antiandrogen, TZP-4238, in the rat.
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Title
Antiandrogenic activity and endocrinological profile of a novel antiandrogen, TZP-4238,
in the rat.
Author
Mieda M; Ohta Y; Saito T; Takahashi H; Shimazawa E; Miyasaka K
Address
Pharmacological Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Source
Endocr J, 41: 4, 1994 Aug, 445-52
Abstract
TZP-4238 is a new potent, orally active steroidal antiandrogen. Antiandrogenic activity
and endocrinological profile of TZP-4238 were investigated in rats, except that
progestational activity was determined in rabbits. TZP-4238 suppressed the testosterone
propionate-induced increases in the weights of the ventral prostate, seminal vesicle and
levator ani in castrated immature male rats. TZP-4238 also decreased the weights of the
ventral prostate, seminal vesicle and levator ani in intact adult male rats, but did not
affect the weight of the testis or the serum concentrations of luteinizing hormone and
testosterone. TZP-4238 did not have such an inhibitory effect on the weight of the adrenal
gland as seen in other steroidal antiandrogens. It exhibited potent progestational
activity. Although TZP-4238 did not exert androgenic or estrogenic activity, it had weak
antiestrogenic activity. These results suggest that TZP-4238 exerts an antiandrogenic
effect on the prostate without any compensatory change in the serum concentration of
luteinizing hormone or testosterone in rats, and it is a useful drug for the treatment of
androgen-dependent diseases such as prostatic hypertrophy and prostatic cancer.
Language of Publication
English
Unique Identifier
96022253
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