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Pyridyl-substituted tetralone derivatives: a new class of nonsteroidal aromatase inhibitors


Abstract:

Structural modification of flavone and flavanone, two weak inhibitors of aromatase, led to the new compounds 1-7, the syntheses of which are described as well as the evaluation of their aromatase and desmolase inhibitory potency. With the exception of 2 all compounds show a stronger inhibition of aromatase than the parent compounds and are more effective inhibitors thanaminoglutethimide (AG), the only commercially available compound. In contrast to AG compounds 1 and 3-7 exhibit no desmolase inhibitory activity. In case of AG this effect leads to undesirable side effects.

 

Author:

Bayer H; Hartmann RW;

 

Address:

Fachrichtung Pharmazeutische Chemie, Universität des Saarlandes.

 

Source:

Arch Pharm (Weinheim), 324:10, 1991 Oct, 815-20

 

Language:

German

 

Unique Identifier:

92215096




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