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Stimulation of hair growth by peptide copper complexes


United States Patent     5,538,945

Pallenberg, et al.     Jul. 23, 1996

Method of promoting hair growth.

 

Inventors:

Pallenberg; Alexander J. (Duval, WA); Patt; Leonard M. (Seattle, WA); Trachy; Ronald E. (Bothell, WA).

 

Assignee:

ProCyte Corporation (Kirkland, WA).

 

Appl. No:

261,475

 

Filed:

Jun. 17, 1944

 

Intl. Cl.: A61K 38/04

Current U.S. Cl.: 514/6; 514/18; 514/19; 530/304

Field of Search: 514/6, 18, 19; 530/304

 

Abstract:

Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides chelated to copper at a molar ratio ranging from about 1:1 to 3:1, with the second position of the peptide from the amino terminus being histidine, arginine or a derivative thereof. The peptide-copper complexes may be formulated for administration by, for example, topical application or injection. Any affliction associate with hairloss, including hairloss associated with both androgenetic and secondaryalopecia, may be treated with the peptide-copper complexes of this invention.

12 Claims, No Drawings

References Cited:

U.S. Patent Documents

3,194,732     Jul., 1965     Neuhauser      167/58

3,551,554     Dec., 1970     Herschler      424/7

3,558,770     Jan., 1971     Gordon et al.     424/80

3,758,682     Sept., 1973     Huber et al.     424/177

3,767,784     Oct., 1973     Gluck      424/28

3,832,338     Aug., 1974     Huber et al.     260/113

4,022,888     May, 1977     Huber et al.     424/177

4,167,945     Sept., 1979     Gottlieb     128/334.R

4,177,261     Dec., 1979     Dietze et al.     424/101

4,263,428     Apr., 1981     Apple et al.     536/17.A

4,287,184     Sept., 1981     Young      424/177

4,440,788     Apr., 1984     Terayama et al.     424/320

4,665,054     May, 1987     Pickart     514/18

4,760,051     Jul., 1988     Pickart     514/6

4,767,753     Aug., 1988     Pickart     514/18

5,120,831     Jun., 1992     Pickart     530/331

5,177,061     Jan., 1993     Pickart     514/18

5,214,032     May, 1993     Pickart     514/16

5,252,559     Oct., 1993     Kronholm et al.     514/18

5,470,876     Nov., 1995     Proctor     514/492

Foreign Patent Documents

327263A1     Aug., 1989     EP

WO87/00427     Jan., 1987     WO

WO88/05653     Aug., 1988     WO

Other References

Uno, H. et al. Macaque and Rodent Models for the Screening of Drugs for Stimulating Hair Growth. Journal of Cutaneous Aging and Cosmetic Dermatology 1, 193-204 (1990).

Metzler, D. “Biochemistry”, Academic Press, NY (1977). See p. 198 Table 4-2 .
Primary Examiner: Nucker; Christine M.
Assistant Examiner: Prickril; Benet
Attorney, Agent or Firm: Seed and Berry




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