United States Patent 5,618,798
Bar-Shalom, et. al. Apr. 8, 1997
Inventors:
Bar-Shalom; Daniel (Rypevaenget 213, DK-2980 Kokkedal, DK); Bukh; Niels (Strandvejen 122, DK-2900 Hellerup, DK).
Appl. No:
247,478
Filed:
May 23, 1994
Related U.S. Application Data:
Continuation of (including streamline cont.) Ser. No. 47,078, Apr. 16, 1993, abandoned, which is a continuation of Ser. No. 613,559, Nov. 21, 1990, abandoned.
Foreign Application Priority Data:
Apr. 20, 1989 [DK] 1918
Intl. Cl.: A61K 31/70
Current U.S. Cl.: 514/53; 514/25; 514/54
Field of Search: 514/23, 25, 53, 59
Abstract:
A method of treating and/or preventing alopecia (baldness, deficient hair growth) comprises administering to a patient in need thereof a therapeutically or prophylactically effective amount of a sulfated mono-, di- or oligosaccharide or a derivative, salt or complex thereof. The saccharide is preferably polysulfated, such as a polysulfated disaccharide, in particular sucrose, or a derivative, complex or salt thereof. Especially interesting polysulfated disaccharides are sucrose pentasulfate, sucrose hexasulfate, sucrose heptasulfate and sucrose octasulfate, e.g. in the form of a potassium or sodium salt, or in the form of sucralfate.
15 Claims, No Drawings
References Cited:
U.S. Patent Documents
4,912,093 Mar, 1990 Michaeli 514/53
Foreign Patent Documents
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Other References
Cassero, Chemical Abstracts, vol. 105 (8) (1986) No. 66249f.
The Merck Manual, 15th ed (1987) pp. 2281-2282.
Couchman et al, Chemical Abstracts, vol. 108 (7), No. 565394.
Gonzalez, et al., Conn’s Current Therapy, 599-603 (1984); Latest Approved Method of Treatment for the Practicing Physician.
W. Scott Brooks, Jr., American Journal of Gastroenterology 80:206-209 (1985); Sucralfate: Nonulcer Uses.
Primary Examiner: Peselev; Elli
Attorney, Agent or Firm: Cooper; Iver P.
