show add
hide add

The penetration enhancer SEPA augments stimulation of scalp hair growth by topical Minoxidil in the balding Stumptail Macaque


Title

The penetration enhancer SEPA augments stimulation of scalp hair growth by topical minoxidil in the balding stumptail macaque.

 

Author

Diani AR, Shull KL, Zaya MJ, Brunden MN

 

Address

Upjohn Company, Kalamazoo, Mich 49001, USA.

 

Source

Skin Pharmacol, 8: 5, 1995, 221-8

 

Hair Loss Study Abstract

The purpose of this study was to determine if the penetration enhancer SEPA (2-n-nonyl-1,3-dioxolane) would augment the scalp hair growth effects of topical minoxidil in the balding stumptail macaque. A 1-in2 area on the balding scalp of 40 adult female monkeys (four drug-treated and four vehicle-treated groups of 5 monkeys each) was topically treated 5 days/week, q.d. or b.i.d., with approximately 250 microliters of minoxidil-SEPA (2.5% minoxidil, weight/volume in 10% SEPA, 25% propylene glycol and 65% isopropyl alcohol), Rogaine topical solution (TS, 2% minoxidil, weight/volume in 20% propylene glycol, 60% ethanol and 20% water) or respective vehicles (without drug) for 16 weeks via paintbrush application. Scalp hair was collected by shaving and vacuuming the dosed area at baseline and at 4-week intervals. The shaved hair was filtered, weighed and recorded as the change from baseline. The q.d. and b.i.d. minoxidil-SEPA groups displayed a significant increase in hair weight compared to their respective vehicles at week 4 whereas q.d. and b.i.d. Rogaine TS groups were not active until week 8 and 12, respectively. Both minoxidil-SEPA treatments produced significantly greater cumulative hair weight over the entire 16-week study compared to either of the Rogaine TS treatments. Comparable increases in cumulative hair weight were evident between q.d. and b.i.d. minoxidil-SEPA groups and between q.d. and b.i.d. Rogaine TS groups.(ABSTRACT TRUNCATED AT 250 WORDS)

 

Language of Publication

English

 

Unique Identifier

96079424




READ THIS NEXT

    Shampoo for Women

    Blonde girl worried about hair loss

    ProTHIK Spray

    Tagamet (Cimetidine)

    Hair Loss Treatment

    man controls hair loss and unhappy gazing at you in the mirror 685775544 bald, baldness, loosing, prevention, hearttrob

    Male Pattern Alopecia

    Pin It on Pinterest

    Share This