United States Patent 5,382,431
Pickart Jan. 17, 1995
Tissue protective and regenerative compositions.
Inventors:
Pickart; Loren R. (Bellevue, WA).
Assignee:
Skin Biology, Inc. (Bellevue, WA).
Appl. No:
954,620
Filed:
Sept. 29, 1992
Related U.S. Application Data:
Intl. Cl.: A61K 37/02
Current U.S. Cl. 424/401; 424/195.1; 424/445; 424/484; 514/ 6; 514/928; 514/887
Field of Search: 424/630, 638, 641, 642, 650, 484, 520, 195.1, 401
Abstract:
Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise precipitates formed by the complexation of peptone digests of various proteins with copper(II) salts, indium (III) salts, tin(II) salts and tin(IV) salts.
13 Claims, No Drawings
References Cited:
U.S. Patent Documents
3,758,682 Sept., 1973 Huber et al. 530/369
4,053,630 Oct., 1977 Yu et al. 424/289
4,156,737 May, 1979 Bertelli 424/287
4,283,386 Aug., 1981 Van Scott et al. 424/70
4,440,754 Apr., 1984 Sorenson 424/140
4,461,724 Jul., 1984 Konishi 260/112.5
4,503,047 May, 1985 Banfi et al. 424/195.1
4,551,431 Nov., 1985 Pierce 424/641
4,760,051 Jul., 1988 Pickart 424/630
4,767,753 Aug., 1988 Pickart et al. 514/18
4,863,897 Sept., 1989 Dede et al. 424/630
5,164,367 Nov., 1992 Pickart 514/6
Foreign Patent Documents
| 66283 | Dec., 1982 | EP | |
| 189182 | Jul., 1986 | EP | |
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| 450398 | Oct., 1991 | EP | |
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| 88/08695 | Nov., 1988 | WO | |
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| 91/03488 | Mar., 1991 | WO | |
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Other References
Sorenson, “Some Copper Coordination Compounds and Their Antiinflammatory and Antiulcer Activities”, Inflammation 1(3):317-331 (1976).
Sorenson et al., “Development of Copper Complexes for Potential Therapeutic Use”, Agents and Actions 8:305-325 (1981).
Johnson et al., “Cytotoxic Chelators and Chelates Inhibition of DNA Synthesis in Cultured Rodent and Human Cells by Aroylhydrazones and by a Copper (II) Complex of Salicylaldehyde Benzoyl Hydrazone”, Inorg. Chem. Acta 67:159-165 (1982).
Raju et al., “Ceruloplasmin, Copper Ions, and Angiogenesis”, J. Natl. Cancer Inst. 69:1183-1188 (Nov., 1982).
Pickart et al., “Inhibition of the Growth of Cultured Cells and an Implanted Fibrosarcoma by Aroylhydrazone Analogs of the Gly-His-Lys-Cu(II) Complex”, Biochem. Pharm. 32:3868-3871 (1983).
Pickart et al., “The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-L-histidyl-L-lysine”, Lymphokines 8:425-446 (1983).
Sorenson, “Copper Complexes: A Physiologic Approach to Treatment of Chronic Diseases”, Comprehensive Therapy 11(4):49-64 (1985).
Bergren et al. “Improved Survival Using Oxygen Free Radical Scavengers in the Presence of Ischemic Bowel Anastomosis”, (Am. Sur. 54:333-336 (Jun., 1988).
Niwa, “Lipid Peroxides and Superoxide Dismutase (SOD) Induction in Skin Inflammatory Diseases, and Treatment with SOD Preparations”, Dermatologica 179 S1: 101-106 (1989).
Primary Examiner: Page; Thurman K.
Assistant Examiner: Spear; James M.
Attorney, Agent or Firm: Townsend and Townsend Khourie and Crew
