United States Patent 5,466,694
Terranova, et. al. Nov. 14, 1995
Compositions for slowing down hair loss and for inducing and stimulating its growth, based on 2,4-diamino-pyrimidine 3-oxide derivatives, and new 2,4-diaminopyrimidine 3-oxide derivatives.
Terranova; Eric (Asnieres, FR); Galey; Jean B. (Paris, FR); Hocquaux; Michel (Paris, FR); Maignan; Jean (Tremblay-les-Gonesse, FR); Tuloup; Remy (Miniac-sous-Becheral, FR).
L’Oreal (Paris, FR).
Jul. 13, 1992
Composition for slowing down hairloss and inducing and stimulating its growth, comprising a compound of the following formula: ##STR1## wherein R(1) and R(3) denote H; R(2) and R(4) denote H or an alkyl; R(5) denotes H, an alkyl, an alkenyl, a cycloalkyl, an aryl, an arylalkyl, a hydroxyalkyl or an aminoalkyl; X denotes H, halogen, alkyl, nitro, benzoyloxy or –NHR(6) where R(6) denotes H, acyl or alkyl; Z denotes sulfur or oxygen, with the proviso that Z denotes sulfur when X denotes H or R(5) denotes aryl; Y denotes oxygen or OSO(3) ; as well as its physiologically acceptable salts.
16 Claims, No Drawings
U.S. Patent Documents
3,382,248 May, 1968 Anthony et al. 540/481
3,637,697 Jan, 1972 Anthony et al. 540/481
4,820,512 Apr, 1989 Grollier 514/256
4,973,474 Nov, 1990 Hocquaux et al. 514/272
5,132,106 Jul, 1992 Tuloup et al. 514/272
Foreign Patent Documents
356271 Jul, 1989 EP
1695959 Oct, 1966 DE
- Chemical Abstracts, vol. 92, 1980, p. 696.
Primary Examiner: Bawa; Raj
Attorney, Agent or Firm: Jacobson, Price, Holman & Stern