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His-Gly-Gly peptide (Procter & Gamble)


United States Patent   5,252,559

Kronholm, et. al.   Oct. 12, 1993



Kronholm; Kurt G. (Oxford, OH); Schwen; Richard J. (Cincinnati, OH); Sine; Mark R. (Morrow, OH); Warren; Raphael (Cincinnati, OH); Wawrzyniak; Cynthia J. (Cincinnati, OH).



The Procter & Gamble Company (Cincinnati, OH).

Appl No: 747,811


Aug. 20, 1991



The present invention relates to a composition for regulating hair growth comprising a safe and effective amount of the tripeptide histidyl-glycyl-glycine, or a derivative thereof, and a pharmaceutically-acceptable carrier.

7 Claims, No Drawings


References Cited:

U.S. Patent Documents

4,665,054     May, 1987     Pickart     541/18

4,760,051     Jul, 1987     Pickart     541/6

Foreign Patent Documents

0415598A1     Mar, 1991     EP

0422765A1     Apr, 1991     EP

88/08695     Nov, 1988     WO

Other References

Bachem Bioscience, Inc., Catalog US 4–1991 p. 295.

Ueda, J., A., Hanaki, N. Yoshida and T. Nakajima-“(^1) H-Nuclear Magnetic Resonance Study of the Interaction of Zinc(II) Ion with a Histidine-Containing Peptide, L-Histidylglycylglycine,” Chem. Pharm. Bull. vol. 33, pp. 3096-3100 (1985).

Yokoyama, A., H. Aiba and H. Tanaka-“Acid Dissociation Constants of Some Histidine-Containing Peptides and Formation Constants of Thier Metal Complexes,” Bulletin of the Chemical Society of Japan, vol. 47, pp. 112-117 (1974).

Schneider, F.-“Tripeptide des Histidins,” Z. Physiol. Chem., vol. 321, pp. 38-48 (1960).

Davis, N. C.-“Action of Proteolytic Enzymes on Some Peptides and Derivatives Containing Histidine,” J. Bio. Chem., vol. 223, pp. 935-947 (1956).


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