Patent:
United States Patent 5,252,559
Kronholm, et. al. Oct. 12, 1993
Inventors:
Kronholm; Kurt G. (Oxford, OH); Schwen; Richard J. (Cincinnati, OH); Sine; Mark R. (Morrow, OH); Warren; Raphael (Cincinnati, OH); Wawrzyniak; Cynthia J. (Cincinnati, OH).
Assignee:
The Procter & Gamble Company (Cincinnati, OH).
Appl No: 747,811
Filed:
Aug. 20, 1991
Abstract:
The present invention relates to a composition for regulating hair growth comprising a safe and effective amount of the tripeptide histidyl-glycyl-glycine, or a derivative thereof, and a pharmaceutically-acceptable carrier.
7 Claims, No Drawings
References Cited:
U.S. Patent Documents
4,665,054 May, 1987 Pickart 541/18
4,760,051 Jul, 1987 Pickart 541/6
Foreign Patent Documents
0415598A1 Mar, 1991 EP
0422765A1 Apr, 1991 EP
88/08695 Nov, 1988 WO
Other References
Bachem Bioscience, Inc., Catalog US 4–1991 p. 295.
Ueda, J., A., Hanaki, N. Yoshida and T. Nakajima-“(^1) H-Nuclear Magnetic Resonance Study of the Interaction of Zinc(II) Ion with a Histidine-Containing Peptide, L-Histidylglycylglycine,” Chem. Pharm. Bull. vol. 33, pp. 3096-3100 (1985).
Yokoyama, A., H. Aiba and H. Tanaka-“Acid Dissociation Constants of Some Histidine-Containing Peptides and Formation Constants of Thier Metal Complexes,” Bulletin of the Chemical Society of Japan, vol. 47, pp. 112-117 (1974).
Schneider, F.-“Tripeptide des Histidins,” Z. Physiol. Chem., vol. 321, pp. 38-48 (1960).
Davis, N. C.-“Action of Proteolytic Enzymes on Some Peptides and Derivatives Containing Histidine,” J. Bio. Chem., vol. 223, pp. 935-947 (1956).
