United States Patent 4,919,664
Oliver, et al. Apr. 24, 1990
Oliver; Roy F. (Department of Biological Sciences University of Dundee, Dundee, GB3); Jahoda; Colin A. B. (Department of Biological Sciences University of Dundee, Dundee, GB3), DD1 .
Feb. 19, 1987
Foreign Application Priority Data:
Feb. 21, 1986 [GB] 860436
Intl. Cl.: A61F 2/10
Current U.S. Cl.: 623/15
Field of Search:/1, 2, 11, 12, 15, 16, 8; /1 R; /240.25
The present invention relates to a method of stimulating hair growth in part of the skin of a mammal. The method comprises selecting lower follicular dermal cells and culturing them. An opening is then formed in the skin and the cultured dermal cells introduced through the opening in the outer epidermis layer of the skin into contact with the dermis, with said cultured dermal cells in association with epidermis cells.
The invention also provides a hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermis cells, as well as such cultured dermal cells for use in the preparation of an injection composition for stimulating hair growth in human skin.
14 Claims, No Drawings
U.S. Patent Documents
4,185,618 Jan, 1980 Corey 128/1.R
4,353,888 Oct, 1982 Sefton 623/11
4,391,909 Jul, 1983 Lim 623/11
4,418,691 Dec, 1983 Yannas et al. 623/15
4,442,655 Apr, 1984 Stroetmann 623/11
4,508,819 Apr, 1985 Rose 128/1.R
4,677,968 Jul, 1987 Krueger 128/1.R
4,721,096 Jan, 1988 Naughton et al. 128/1.R
4,742,120 Feb, 1987 Nevo et al. 623/15
Foreign Patent Documents
0013394 Jul, 1980 EP
0107885 May, 1984 EP
Jahoda et al., Vibrissa Dermal Papilla Cell Aggregative Behaviour in vivo and in vitro, J. Embryol. Exp. Morph., 79, 211-224 (1984).
Jahoda et al., Introduction of Hair Growth by Implantation of Cultured Dermal Papilla Cells, Nature, vol. 311, No. 5986, pp. 560-562, Oct. 1984.
Primary Examiner: Apley; Richard J.
Assistant Examiner: Isabella; David J.
Attorney, Agent or Firm: Irfan; Kareem M.