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Stimulation of hair growth by peptide copper complexes

United States Patent     4,919,664

Oliver, et al.      Apr. 24, 1990



Oliver; Roy F. (Department of Biological Sciences University of Dundee, Dundee, GB3); Jahoda; Colin A. B. (Department of Biological Sciences University of Dundee, Dundee, GB3), DD1 .


Appl. No:




Feb. 19, 1987


Foreign Application Priority Data:

Feb. 21, 1986 [GB]     860436

Intl. Cl.: A61F 2/10

Current U.S. Cl.: 623/15

Field of Search: 623/1, 2, 11, 12, 15, 16, 8; 128/1 R; 435/240.25



The present invention relates to a method of stimulating hair growth in part of the skin of a mammal. The method comprises selecting lower follicular dermal cells and culturing them. An opening is then formed in the skin and the cultured dermal cells introduced through the opening in the outer epidermis layer of the skin into contact with the dermis, with said cultured dermal cells in association with epidermis cells.

The invention also provides a hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermis cells, as well as such cultured dermal cells for use in the preparation of an injection composition for stimulating hair growth in human skin.

14 Claims, No Drawings

References Cited:

U.S. Patent Documents

4,185,618     Jan, 1980     Corey     128/1.R

4,353,888     Oct, 1982     Sefton     623/11

4,391,909     Jul, 1983     Lim     623/11

4,418,691     Dec, 1983     Yannas et al.     623/15

4,442,655     Apr, 1984     Stroetmann     623/11

4,508,819     Apr, 1985     Rose     128/1.R

4,677,968     Jul, 1987     Krueger     128/1.R

4,721,096     Jan, 1988     Naughton et al.     128/1.R

4,742,120     Feb, 1987     Nevo et al.     623/15


Foreign Patent Documents

0013394     Jul, 1980     EP

0107885     May, 1984     EP

Other References

Jahoda et al., Vibrissa Dermal Papilla Cell Aggregative Behaviour in vivo and in vitro, J. Embryol. Exp. Morph., 79, 211-224 (1984).

Jahoda et al., Introduction of Hair Growth by Implantation of Cultured Dermal Papilla Cells, Nature, vol. 311, No. 5986, pp. 560-562, Oct. 1984.
Primary Examiner: Apley; Richard J.
Assistant Examiner: Isabella; David J.
Attorney, Agent or Firm: Irfan; Kareem M.


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