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Stimulation of hair growth with minoxidil and a 5.alpha.-reductase inhibitor

United States Patent     5,578,599

Diani, et al.      Nov. 26, 1996



Diani; Arthur R. (Mattawan, MI); Buhl; Allen E. (Portage, MI); Schostarez; Heinrich J. (Portage, MI).



The Upjohn Company (Kalamazoo, MI).


Appl. No:




Jan. 20,1995


Related U.S. Application Data:

Continuation of (including streamline cont.) Ser. No. 9,451, Jan. 27, 1993, abandoned, which is a continuation of Ser. No. 565,777, Aug. 10, 1990, abandoned.

Intl. Cl.: A61K 31/505, A61K 31/44

Current U.S. Cl.: 514/275; 514/284

Field of Search: 514/284, 275



An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium channel openers, such as minoxidil, cromakalim, pinacidil, or a compound selected frown the classes of s-triazine, thiane-1-oxide, benzopyran and pyridinopyran compounds; and a 5.alpha.-reductase inhibitors, 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one. The method comprises administering an effective amount of the potassium channel opener and administering an effective amount of the 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one whereby the promotion of hair growth is increase over the sole administration of the potassium channel opener.

4 Claims, No Drawings

References Cited:

U.S. Patent Documents

4,139,619     Feb, 1979     Chidsey, III     424/45

4,596,812     Jun, 1986     Chidsey, III et al.     514/256

4,684,635     Aug, 1987     Orentreich et al.     514/170

5,026,691     Jun, 1991     Kligman et al.     514/171

Foreign Patent Documents

0285382A2     Oct, 1988     EP

3615396A     Nov, 1987     DE

1305017A     Dec, 1989     JP

WO87/00427     Jan, 1987     WO

Primary Examiner: Cintins; Marianne M.
Assistant Examiner: Moezie; M.
Attorney, Agent or Firm: Corneglio; Donald L.


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