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HAIR LOSS TREATMENTS
Drug-induced hair lossThis list is currently under development and is nowhere near complete. Note: This is not a list of products, but active agents and substances known or purported to cause hair loss as a side effect. Drug induced hair loss varies by drug. Some drugs you would have to be one in 1 million to experience …Continue Reading
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Medical treatment of male pattern alopecia (androgenic alopecia)
Hair Loss Study Abstract The causes and potential causes of androgenic alopecia in men and women are discussed. The scientific attempts at reversing this process are detailed including use of estrogen, thyroid, progesterone, and minoxidil. At present, the practical approach for the clinician is to ascertain in females that an androgen overproduction syndrome is not …Continue Reading
New natural hair loss treatment for hair loss in Phase II trials
More information has been disclosed regarding a new natural treatment for hair loss that is being clinically studied for hair loss. The product is from an extract from a single plant species and is called P45. It is currently in Phase II clinical testing. The following information is from Phytopharm’s website regarding P45: Based on …Continue Reading
Changes in the amounts of cytochromes P450 in rat hepatic microsomes produced by cyclosporin A.
Hair Loss Study Abstract 1. The effect of cyclosporin A, an immunosuppressive drug, on the levels of individual cytochromes P450 of rat liver was studied by immunoblotting with specific antibodies. Changes in the metabolic activities of the microsomal enzymes were similarly studied. 2. Total P450 was decreased by treatment with cyclosporin A for 17 days. …Continue Reading
Mice Grow Green Glowing Hair
Hair Loss Study Abstract A new method that allows mice to grow genetically modified hair may provide hope for a variety of dermatological conditions. Genetic modification of the hair shaft provides an attractive route for altering the appearance of hair and for treating dermatological disorders like acne and various types of baldness. However, efficient modification …Continue Reading
Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men
Hair Loss Study Abstract To objectively measure the effects of a 5 alpha-reductase inhibitor on erectile function, we studied 20 sexually active men (aged 41-64 yr) during double blind, randomized administration of 5 mg/day finasteride (F) or placebo (P). Serum testosterone and dihydrotestosterone (DHT) were measured every 4 weeks. Sleep-related erections were assessed with comprehensive …Continue Reading
Hair Loss Treatment: RegenHair
Hair Loss Treatment Type A combination of essential oils, vitamins and minerals beneficial to hair in a cream. Availability Online. Notes RegenHair is a cream containing natural ingredients that is applied 3-4 times a week for people suffering from hair loss. Claimed Results Regenhair’s customers have reported a decrease in excessive hair …Continue Reading
Hair Loss Treatment: Simvastin
Hair Loss Treatment Type Cholesterol Lowering/Weak Antiandrogen Availability Prescription. Notes Simvastin is a drug prescribed to lower cholesterol levels for men and women for whom excercise and diet is not enough. Simvastin is a very weak antiandrogen. In fact, it is so weak that the only reason I am including it is for …Continue Reading
A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors.
Hair Loss Study Abstract Since mammalian skin expresses the enzymatic apparatus for melatonin synthesis, it may be an extrapineal site of melatonin synthesis. However, evidence is still lacking that this is really the case in situ. Here, we demonstrate melatonin-like immunoreactivity (IR) in the outer root sheath (ORS) of mouse and human hair follicles (HFs), …Continue Reading
The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial
Hair Loss Study Abstract BACKGROUND: Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit. OBJECTIVES: The purpose of this 6-month, 200-patient, randomized, investigator-blinded, parallel-group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a …Continue Reading
Smoking Increases DHT, the Hormone Related to Hair Loss
It is often asked by visitors of this site whether smoking can affect hair loss. The answer may be yes. According to a recent study by the Harvard School of Public Health, smoking can increase almost all the major androgenic hormones including DHEA, androstenedione, testosterone, and dihydrotestosterone (DHT), the hormone most closely linked to hairloss. …Continue Reading
The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia.
Hair Loss Study Abstract BACKGROUND: It is generally believed that dihydrotestosterone is one of the pivotal mediators of hair loss in androgenetic alopecia (AGA). Finasteride, which blocks the conversion of testosterone to dihydrotestosterone, has now become an integral part of the current treatment approaches for male AGA. Several lines of evidence support the notion that …Continue Reading
A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women.
Hair Loss Study Abstract Enhanced 5 alpha-reductase activity has been found in the skin of the majority of women with hirsutism. Finasteride is a specific competitive inhibitor of 5 alpha-reductase, preferentially inhibiting the type 2 isoenzyme. Therefore, we randomly assigned 14 hirsute women in a 2:1 ratio to 1 of 2 treatment arms: 1) finasteride …Continue Reading
Five-year follow-up of patients with benign prostatic hyperplasia treated with finasteride
Hair Loss Study Abstract In 18 of 55 original patients who completed 5 years of treatment with finasteride, significant reductions in prostate size were noted at 1 year and sustained thereafter. Symptom scores in these same patients were significantly improved or stable over the 5 years while maximal urinary flow rates were unchanged. Data from …Continue Reading
Norplant and its side effects
Hair Loss Study Abstract Norplant is a subcutaneous contraceptive with levonorgestrel. From March to October 1993. Norplant was implanted in 58 women and its side effects were observed for a period of six months. No pregnancy occurred during the study period. Almost all the women experienced irregular menstruations or amenorrhea. The most frequent side effect …Continue Reading
Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle
Hair Loss Study Abstract BACKGROUND: Minoxidil has been widely used to treat androgenetic alopecia, but little is known about its pharmacological activity or about the identity of its target cells in hair follicles. We hypothesized that minoxidil has direct effects on the proliferation and apoptosis of dermal papilla cells (DPCs) of human hair follicle. OBJECTIVE: …Continue Reading
Scientists Seek Gene Therapy for Baldness
By studying baldness in an immunodeficient patient, researchers believe they are moving closer to identifying the genes governing hair growth — and to gene therapies aimed at treating baldness. “Understanding the genetic underpinnings of the hair cycle will provide much better and rationally designed targets for the treatment of male-pattern baldness and other hair loss …Continue Reading
Hair loss in women with hyperandrogenism: four cases responding to finasteride
Hair Loss Study Abstract Oral finasteride, a type II 5 alpha-reductase inhibitor, has been shown to increase hair growth and slow progression of thinning in men with androgenetic or male pattern balding (Hamiliton type) but has no affect on hair growth in postmenopausal women with female pattern hair loss (Ludwig type). We describe 4 cases …Continue Reading
FDA Advisory Committee Recommends Rogaine Extra Strength for OTC Sales
By a vote of 13-4, the Nonprescription Drugs Advisory Committee and the Dermatologic and Ophthalmic Drugs Advisory Committee today recommended that based on safety and effectiveness of the product, Rogaine Extra Strength for Men should be made available for over-the-counter (OTC) sales. “We are extremely pleased with the recommendation from the advisory panel,” said Michael …Continue Reading
Limitations of human occipital scalp hair follicle organ culture for studying the effects of minoxidil as a hair growth enhancer
Hair Loss Study Abstract Minoxidil induces new hair growth in approximately one-third of patients with androgenetic alopecia after 1 year of treatment. With several conflicting reports in the literature based on small-scale studies, the current study aimed to clarify whether organ culture of human scalp anagen VI hair follicles is a suitable in vitro test …Continue Reading
Phytopharm P45 Studies Fail
The following text was part of a press release from Phytopharm regarding their new natural treatment under study, P45. Phytopharm plc (PYM: London Stock Exchange) (“Phytopharm”) announces today the results of its Phase II clinical trial of P45, a topical cream derived from a medicinal plant for the treatment of hairloss (alopecia). This condition includes …Continue Reading
Hair loss. What causes it and what can be done about it.
Hair Loss Study Abstract Although both men and women throughout history have seen hair as an important aspect of appearance, it is especially important today, in light of the great emphasis on youthfulness. A new interest in preventing baldness has been stimulated recently by the publicity given to certain products now under investigation that have …Continue Reading
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
Hair Loss Study Abstract BACKGROUND: Male pattern hair loss (MPHL) is a potentially reversible condition in which dihydrotestosterone is an important etiologic factor. OBJECTIVE: Our aim was to evaluate the efficacy of the type 1 and 2 5alpha-reductase inhibitor dutasteride in men with MPHL. METHODS: Four hundred sixteen men, 21 to 45 years old, were …Continue Reading
Drug-induced hair loss and hair growth. Incidence, management and avoidance
Hair Loss Study Abstract A large number of drugs may interfere with the hair cycle and produce hair loss. Drugs may affect anagen follicles through 2 main different modalities: (i) by inducing an abrupt cessation of mitotic activity in rapidly dividing hair matrix cells (anagen effluvium) or (ii) by precipitating the follicles into premature rest …Continue Reading
Polymorphism of the androgen receptor gene is associated with male pattern baldness.
Hair Loss Study Abstract The common heritable loss of scalp hair known as male pattern baldness or androgenetic alopecia affects up to 80% of males by age 80. A balding scalp is characterized by high levels of the potent androgen dihydrotestosterone and increased expression of the androgen receptor gene. To determine if the androgen receptor …Continue Reading
Hair growth effects of oral administration of Finasteride, a steroid 5a-reductase inhibitor, alone and in combination with combination of topical minoxidil in the balding stumptail macaque.
Abstract: A 5a-reductase inhibitor, finasteride, was administered orally at 0.5 mg/day, alone or in combination with topical 2% minoxidil, for 20 weeks to determine the effects on scalp hair growth in balding adult male stumptail macaque monkeys. A 7-day dose-finding study showed that both 0.5-and 2.0-mg doses of the drug produced a similar diminution in …Continue Reading