The role of oral contraceptives in the treatment of hyperandrogenic disorders

Hair Loss Study Abstract The clinical manifestations associated with hyperandrogenism, such as hirsutism and acne, are disturbing to most patients. In addition to correcting androgen-related problems, concerns such as contraception or other metabolic problems (for example, lipid/lipoprotein abnormalities, diabetes, hypertension) associated with these disorders and the effects of unopposed estrogen on the endometrium also need   …Continue Reading

The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial

Hair Loss Study Abstract BACKGROUND: Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit. OBJECTIVES: The purpose of this 6-month, 200-patient, randomized, investigator-blinded, parallel-group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a   …Continue Reading

The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia.

Hair Loss Study Abstract BACKGROUND: It is generally believed that dihydrotestosterone is one of the pivotal mediators of hair loss in androgenetic alopecia (AGA). Finasteride, which blocks the conversion of testosterone to dihydrotestosterone, has now become an integral part of the current treatment approaches for male AGA. Several lines of evidence support the notion that   …Continue Reading

Polymorphism of the androgen receptor gene is associated with male pattern baldness.

Hair Loss Study Abstract The common heritable loss of scalp hair known as male pattern baldness or androgenetic alopecia affects up to 80% of males by age 80. A balding scalp is characterized by high levels of the potent androgen dihydrotestosterone and increased expression of the androgen receptor gene. To determine if the androgen receptor   …Continue Reading

Hair growth effects of oral administration of Finasteride, a steroid 5a-reductase inhibitor, alone and in combination with combination of topical minoxidil in the balding stumptail macaque.

Abstract: A 5a-reductase inhibitor, finasteride, was administered orally at 0.5 mg/day, alone or in combination with topical 2% minoxidil, for 20 weeks to determine the effects on scalp hair growth in balding adult male stumptail macaque monkeys. A 7-day dose-finding study showed that both 0.5-and 2.0-mg doses of the drug produced a similar diminution in   …Continue Reading

New Gene Research Grows Hair in Mice

Wig makers, tremble! Purveyors of hair restorer, whether F.D.A.-approved or purest snake-oil, brush up on bankruptcy law! Messrs. Michael Milken, Ted Danson, Marv Albert and all hairpiece wearers; Governor Ventura and the proudly bald, and all those about to become so — listen carefully, for a sudden ray of hope is playing upon all your   …Continue Reading

Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results

Hair Loss Study Abstract BACKGROUND: We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA). OBJECTIVE: Our purpose was to evaluate the effects of finasteride on hair weight and count over 4 years in men with AGA. METHODS: Men with AGA were   …Continue Reading

The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid-oxidoreductase enzyme activity

Hair Loss Study Abstract In concentrations probably exceeding those achieved in vivo, the cholesterol lowering compound simvastatin was found to suppress the synthesis of the androgens androstenediol and testosterone in vitro by human testicular homogenates. It was demonstrated that simvastatin in addition to its known inhibitory effect on HMG-CoA reductase activity, also affects the later   …Continue Reading

Update on Minoxidil 5% and Propecia 3rd/4th Year Hair Loss Study Results

Updates on the two FDA approved treatments for hair loss were announced at this weeks American Academy of Dermatology (AAD) meeting in San Francisco, CA. First to report was Dr. Ron Trancik of Phamacia & Upjohn, who announced that 5% Minoxidil is still being studied for review by the FDA for approval in women. Two   …Continue Reading

Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)

Hair Loss Study Abstract Green tea is a popular worldwide beverage, and its potential beneficial effects such as anti-cancer and anti-oxidant properties are believed to be mediated by epigallocatechin-3-gallate (EGCG), a major constituent of polyphenols. Recently, it was reported that EGCG might be useful in the prevention or treatment of androgenetic alopecia by selectively inhibiting   …Continue Reading

RU 58841(myristate) pro-drug development for topical treatment of acne and androgenetic alopecia

Hair Loss Study Abstract Acne and androgenetic alopecia are linked to androgen effects and therefore should improve following topical application of antiandrogens. We present a new antiandrogen prodrug, RU 58841-myristate (RUM) for topical therapy. Almost devoid of affinity to the androgen receptor, as derived from investigations in the mouse fibroblast cell line 29 +/GR +,   …Continue Reading

Mites Indicated In All Baldness Cases

In a second recent report announcing a factor contributing to baldness, a dermatologist reports that a common mite is implicated in all cases of human hairloss. Dr. William Regelson, an expert with the Medical College of Virginia, told an annual meeting of dermatologists in Miami that while the mite has been known since the 1840s   …Continue Reading

Hair loss Treatment: Vitamin B6 (Pyridoxal/Pyridoxine HCL)

Hair Loss Treatment Type Essential Vitamin   Availability Grocery & Health Stores.   Notes It has been shown in previous studies on Zinc that combined with Vitamin B6, it was markedly able to inhibit the conversion of Testosterone to DHT in the skin.   There are now studies that show that specific types of B6   …Continue Reading

Propecia phase III 5 year hair loss results

The 4th and 5th year Propecia results were announced today at the American Academy of Dermatology Meeting in Washington, DC. Dr. Elise Olsen presented the results during her presentation on pattern hair loss in men and women at the ‘Hair’ symposium of the meeting. The 5 year results presented a mixture of good and bad   …Continue Reading

Protein Grows Thicker Hair

No more comb-overs. An end to hair plugs. Rugs go back on the floor where they belong. If an experiment in mice works in men, it may be possible to grow thicker hair, scientists in Boston, Massachusetts said Thursday. They said they found a protein normally associated with blood-vessel growth that makes hair follicles bigger.   …Continue Reading

Inhibition of androgen metabolism and binding by a liposterolic extract of “Serenoa repens B” in human foreskin fibroblasts.

Hair Loss Study Abstract We previously suggested [Steroids 33, (1979) 3; Steroids 37, (1981) 6] that cultured genital skin fibroblasts should prove useful for screening of potential antiandrogens in human and living target cells. “Serenoa repens” lipidic extract (S.R.E.) was recently reported (Br. J. Pharmacol., in press) to inhibit androgen action in animals. The present   …Continue Reading

Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism.

Hair Loss Study Abstract Finasteride is not necessarily effective on all of the male pattern baldness (MPB) patients. To know any factor which correlates with the effectiveness of finasteride, the polymorphism of androgen receptor (AR) gene was analyzed. Symptoms of the 488 MPB patients (18-62 y) before and after treatment with total dose of 10   …Continue Reading

Five-year follow-up of patients with benign prostatic hyperplasia treated with finasteride

Hair Loss Study Abstract In 18 of 55 original patients who completed 5 years of treatment with finasteride, significant reductions in prostate size were noted at 1 year and sustained thereafter. Symptom scores in these same patients were significantly improved or stable over the 5 years while maximal urinary flow rates were unchanged. Data from   …Continue Reading

Inactivation of rat hepatic cytochrome P-450 by spironolactone

Hair Loss Study Abstract Administration of antimineralocorticoid spironolactone (SPL) to rats results in modest destruction of hepatic cytochrome P-450 with parallel loss of heme. This process is accentuated by pretreatment with dexamethasone (DEX), an inducer of cytochrome P-450p and is associated with marked functional loss of cytochrome P-450p-dependent hydroxylases. Cytochrome P-450 destruction may be replicated   …Continue Reading

Increased cAMP levels in human hair follicles

Hair Loss Study Abstract Local therapy with trichoriboside and trichosaccharide, which have been found to be beneficial for scalp hair maintenance in adult males affected by androgenic alopecia, was found to increase cAMP levels in human scalp hair follicles. The increase was significant in men affected by androgenic alopecia, whereas it was not significant in   …Continue Reading

Favorable effects of estrogens and progesterones on general diseases

Hair Loss Study Abstract Estrogens and progestagens exert positive effects on some general diseases as iron deficiency, anemia, premenstrual syndrome, intermenstrual migraine, akne, seborrhoea, hirsutism, androgenetic alopecia, slerodermia, rheumatoid arthritis, osteoporosis and depressive disorders. The mechanism of action and the mode of treatment in such cases are discussed   Author Lauritzen C; Lehmann WD     …Continue Reading

Sulfasalazine for Alopecia

Hair Loss Study Abstract Sulfasalazine is used as a therapy for various autoimmune conditions, including psoriasis; its effectiveness is presumed to be the result of its immunomodulatory effects. We have treated patients with severe alopecia areata with sulfasalazine as part of our dermatology practice and have noticed cosmetically acceptable regrowth in 23% of patients in   …Continue Reading

An open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopecia

Hair Loss Study Abstract Androgenetic alopecia (AGA) is undoubtedly the most common form of hair loss in males. It is a condition which may cause cosmetic and psychosocial problems in androgen-dependent cases. In this open, randomized and comparative study we evaluated the efficacy of oral finasteride and 5% topical minoxidil treatment for 12 months in   …Continue Reading

Estrogen can turn on male genes

Talk about an odd couple. A new study suggests that estrogen, frequently considered the quintessential female hormone, can turn on genes by binding to the same protein that responds to testosterone and other androgens, the so-called male hormones. This unexpected union only activates genes in the presence of a matchmaker protein called ARA-70, however reports   …Continue Reading

Aerobics may lower male hormones

Men experiencing hair loss may want to take up a little aerobic exercise. According to an Associated Press article this week, men who do a lot of endurance exercising have lower levels of male sex hormones than other men.  The research indicates that men who do a lot of running experience lower testosterone levels even   …Continue Reading