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Compositions and methods for promoting hair growth


Patent:

United States Patent   5,407,944

Goldman    Apr. 18, 1995

Inventors:

Goldman; Boris E. (2019 Breton, S.E., Grand Rapids, MI 49546).

Appl. No:

020,202

Filed:

Feb. 19, 1993

Abstract:

The present invention provides compositions and methods for promoting hair growth. The methods generally comprise the administration to a patient of a therapeutically effective amount of the compositions of the present invention which employ a vasodilator in combination with estradiol and/or a 5-.alpha.-reductase inhibitor in a pharmaceutically acceptable vehicle. The compositions and methods of the present invention are suitable for the treatment of baldness, in particular, male pattern baldness.

36 Claims, 4 Drawing Figures

 

References Cited:

U.S. Patent Documents

4,596,812     Jun, 1986     Chidsey, III et al.     514/256

5,015,470     May, 1991     Gibson     424/70

Other References

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Thigpen, A. E. et al., “Tissue Distribution and Ontogeny of Steroid 5 Alpha-Redustase Isozyme Expression,” J. Clin. Invest. 92(2):903-10 (1993).

Mellin, T. N. et al., “Azasteroids as Inhibitors of Testosterone 5 Alpha-Redustase in Mammalian Skin,” J. Steroid Biochem. Mol. Biol. 44(2):121-31 (1993).

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Diani, A. R. et al., “Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque,” J. Clin. Endocrinol. Metab. 74(2):345-50 (1992).

Young, M. W., “American Association of Anatomists,” Anatomical Record 100:728 (1948).

Young, M. W., “American Association of Anatomists,” Anatomical Record 97:378 (1947).

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Orentreich, N. et al. “Biology of Scalp Hair Growth,” Clin. Plast. Surg. 9:197:205 (1982).

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Hamilton, J. B. “Patterned Loss of Hair in Man: Types and Incidence,” Ann. NY Acad. Sci. 53:709:728 (1951).

Klemp. P. et al., “Subcutaneous Blood Flow in Early Male Pattern Baldness,” J. Invest. Derm. 92(5):725-726 (1989).

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Dingman, R. O. et al., “The Surgical Repair of Traumatic Defects of the Scalp,” Clin. Plast. Surg. 9:131-144 (1982).

Hunt, et al., “The Effect of Varying Ambient Oxygen Tensions on Wound Metabolism and Collagen Synthesis,” Surg. Gyn. Ob. 135:561-566 (1972).

Marshall, R. C. et al., “Structure and Biochemistry of Mammalian Hard Keratin,” 4:47-83 (1991).

Buxman, M. et al., “Keratin Cross-Linking and Epidermal Transglutaminase,” J. Invest. Derm. 65:107-112 (1975).

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Sawaya, M. E. et al., “Immunohistochemical Distribution of Aromatase and 3B-hydroxysteroid Dehydrogenase in Human Hair Follicle and Sebaceous Gland,” J. Cutan. Pathol. 19:309-314 (1992).

Sawaya, M. E. “Steroid Chemistry and Hormone Controls During the Hair Follicle Cycle,” Ann. NY Acad. Sci. 642:376-383 (1991) and (Abstract).

Schweikert, H. U. et al., “Regulation of Human Hair Growth by Steroid Hormones. 1. Testosterone Metabolism in Isolated Hairs,” J. Clin. Endocrin. Metab. 38:811-819 (1974).

Orfanos, C. E. “Lokaltherapie der Alopecia Androgentica mit 17 .alpha.-Ostradiol,” Dermatologica 161:124-132 (1980).

Takayasu, S. et al., “The Conversion of Testosterone to 17.beta.-hydroxy-5.alpha.-androstan-3-one (Dihydrotestosterone) by Human Hair Follicles,” J. Clin. Endocrinol. Metab. 34:1098 1101(1972).

Anderson, R. D., “Expansion-Assisted Treatment of Male Pattern Baldness,” Clin. Plast. Surg. 14:477-489 (1987).

Herring, B. D., “Unravelling the Pathophysiology of Male Pattern Baldness,” J. Nation. Med. Assoc. 77:142 and 145 (1985).

Freedberg, I. M., “Biochemistry of Keratinization in Hair: Protein Synthesis, Pathways and Controls,” pp. 105-112 (1987).

Hamilton, J. B., Am. J. Anat. 71:451-480 (1942).

Tang, S. et al., J. Biol. Chem. 244:6584 (1969).
Primary Examiner: Prescott; Arthur C.
Attorney, Agent or Firm: Harness, Dickey & Pierce




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